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Projects
Subject Areas
The content of the DigiStrucMed projects offered can be divided into four thematic areas based on their fields of application and objectives:
- Tools and technologies for physicians. Digitalization processes in medicine, such as electronic medical history tools, the introduction of structured data collection, or digital communications in studies—these should be compared with analog processes, or novel methods should be developed for the analysis of health-related data. Furthermore, decision support systems should be developed or evaluated by linking already digitized data and using appropriate algorithms.
- Tools and technologies for patients: Projects in the second thematic area focus on developing technologies designed to empower patients to make informed decisions (informed patient), as well as, in a second area of focus, technologies intended to simplify patient follow-up and enable, for example, home monitoring.
- Analytical technologies for diagnostics and treatment: Analytical technologies for laboratory and imaging diagnostics, as well as for predicting treatment effectiveness and resistance, are being developed and evaluated for the assessment of disease progression and for prevention. These can be implemented, for example, using artificial intelligence methods (e.g., image analysis based on neural networks) or focus on big data, databases, and data mining.
- Robotics and assistive systems: The potential applications of robotic and assistive systems in Clinical Departments and Nursing are being investigated.
ID | Title | Project Leader Medicine | Project Leader Informatics |
| AI for Precision Renal Allograft Diagnostics (AlloPaRD-AI) | Prof. Dr. Jan Hinrich Bräsen Institute of Pathology Hannover Medical School | Prof. Dr. Helena Zacharias Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School | |
| Using AI to predict cardiovascular risk of preeclampsia after pregnancy | PD Dr. Lars Brodowski Department ofGynecology and Obstetrics Hannover Medical School | Prof. Dr. Jana Hutter Institute for Information Processing Leibniz University Hannover | |
| Bridging the Gap: Characterizing Microbiome-Inflammation Endotypes in Bronchiectasis | Prof. Dr. Anna-Maria Dittrich Pediatric Pulmonology, Allergology, and Neonatology Hannover Medical School | Dr. Jan Fuge DZL Hannover Medical School | |
| Population-based risk factors for synchronous multi-cancer development | Prof. Dr. Michael Heuser Department of Hematology and Oncology Martin Luther University Halle-Wittenberg | Assistant Professor Thomas Schmid, Martin Luther University Halle-Wittenberg | |
| Understanding the associations between choroid plexus features and white matter lesion characteristics in inflammation-mediated depression – An AI-assisted visual analytics approach | Prof. Dr. Hannah Maier Department of Psychiatry, Social Psychiatry, and Psychotherapy Hannover Medical School | Prof. Dr. Steffen Oeltze-Jafra Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School | |
| AUTOFLIS – AI-based MRI analysis using the Functional Liver Imaging Score: Automation and Comparison with Relative Enhancement in PSC Patients and Controls | Prof. Dr. Kristina Ringe Department of Diagnostic and Interventional Radiology , Hannover Medical School | Prof. Dr. Andrea Schenk Fraunhofer Institute for Digital Medicine MEVIS | |
| Large-scale characterization of antimicrobial resistance plasmids and their host-lineage associations in clinical Enterobacterales | Prof. Dr. Dirk Schlüter Department of Medical Microbiology Hannover Medical School | Prof. Dr. Marco Galardini Molecular Bacteriology TWINCORE | |
| App-based single-call activation, electronic communication, and documentation in endovascular thrombectomy for stroke to optimize procedure times | PD Dr. Hans Worthmann Department of Neurology Hannover Medical School | Mareike Schulze, B.S. in Business Informatics Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School
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ID | Title | Project Leader Medicine | Project Leader Informatics |
P01 | Development of a bioinformatics tool to predict clinical responses to CFTR modulator therapy by integrating microbial metagenomics, inflammatory cell transcriptomics, and secretomics | Prof. Dr. med. Anna-Maria Dittrich Pediatric Pulmonology, Allergy, and Neonatology, Hannover Medical School | Prof. Dr. Dipl.-Ing. Wolfgang Nejdl Institute of Data Science, L3S Research Institute, Leibniz University Hannover |
P02 | Automation of ISHAK Scoring: Machine-Based Development of an Unsupervised Liver Fibrosis Index | PD Dr. Nagoud Schukfeh Department of Pediatric Surgery, Hannover Medical School | Prof. Dr. Andrea Schenk Fraunhofer Institute for Digital Medicine MEVIS |
P03 | Large Language Models to Support Patients with Hereditary Breast and Ovarian Cancer: Opinion Research, Development of Quality Standards, and Implementation in a Mobile App | Dr. rer. nat. Beate Vajen Department of Human Genetics, Hannover Medical School | Dr. rer. nat. Dominik Wolff Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
P04 | Structured Digital Learning and AI Optimization for Heart Failure Education | Prof. Dr. med. David Duncker, MD Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School | Prof. Dr. Maria-Esther Vidal Data Science Institute, Leibniz University of Hannover |
P05 | Analysis of broad interdisciplinary data sets from patients with transthyretin amyloidosis using classical statistical and advanced machine-learning methods to improve the prediction of disease progression and outcomes | Prof. Dr. med. Udo Bavendiek Department of Cardiology and Angiology, Hannover Medical School Amyloidosis Center Lower Saxony, Hannover Medical School | Dr. Matthias Gietzelt Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
P06 | CLARA - Cognitive Language Assistant and Retrieval Aid | PD Dr. med. Hans Worthmann Department of Neurology, Hannover Medical School | Mareike Schulze, B.S. in Information Systems Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
P07 | Can machines detect information that we cannot? Developing an algorithm capable of diagnosing patients with functional tic-like movement disorders using machine learning. | Prof. Dr. Kirsten Müller-Vahl Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School | Prof. Dr. Dr. Lars Schmidt-Thieme Information Systems and Machine Learning Lab, University of Hildesheim |
P08 | Establishing Oxford Nanopore Sequencing technology as a rapid method for karyotyping in clinical practice | Prof. Dr. Michael Heuser Department of Internal Medicine IV, University Hospital Halle (Saale) | Prof. Dr. Matthias Müller-Hannemann Institute for Computer Science, Department of Data Structures and Efficient Algorithms, Faculty of Natural Sciences III, Halle (Saale)
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ID | Project Title | Project Lead | Cooperation Partner |
| P01 | Computerized interpretation of fetal heart rate during labor, including clinical parameters | PD Dr. Lars Brodowski
| Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P02 | Development, feasibility, and usability of a generic and secure application powered by a large language model, with a focus on patient education for patients with implantable defibrillators and heart failure | Prof. Dr. David Duncker Hannover Heart Rhythm Center Department of Cardiology and Angiology Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P03 | Algorithm development using machine learning to distinguish between tics and functional tic-like movements in videos | Prof. Dr. Kirsten Müller-Vahl Clinic of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School | Institute for Information Processing, Leibniz University Hannover Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School |
| P04 | User-independent AI-based MRI analysis of hepatobiliary function in patients with primary sclerosing cholangitis (PSC) | Prof. Dr. Kristina Ringe Department of Diagnostic and Interventional Radiology Hannover Medical School | Fraunhofer Institute for Digital Medicine MEVIS |
| P05 | Individualizing HCC surveillance based on an integrative systems medicine approach | Prof. Dr. Markus Cornberg Centre for Individualised Infection Medicine (CiiM), Hannover, Dept. of Gastroenterology, Hepatology and Endocrinology Hannover Medical School | Division of Data Science in Biomedicine Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P06 | Implementation of an AI-supported mental health app in psychocardiology | Prof. Dr. Kai G. Kahl Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School | Institute for Business Informatics |
| P07 | Identification of biomarkers in hepatocellular carcinoma patients by combining advanced imaging techniques with machine learning approaches | PD Dr. Anna Saborowski Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P08 | Digital Twin for predicting road traffic injuries | Prof. Dr. Thomas M. Deserno Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School | Clinical Department of Trauma Surgery Hannover Medical School |
| P09 | Fibromyalgia Rheumatica and Digital Pain Drawing (FibRDraw) | Prof. Dr. Georg Behrens Department of Rheumatology and Immunology Hannover Medical School | Institute for Information Engineering, Ostfalia University of Applied Sciences Department of Psychosomatics and Psychotherapy |
| P10 | Evaluation of the clinical utility of wearable fitness tracking devices to predict liver-related outcomes in patients with liver cirrhosis | Prof. Dr. Benjamin Maasoumy Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School | Division of Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School Trauma Department, Orthogeriatric Unit, Hannover Medical School |
ID | Project Title | Project Lead | Cooperation Partner |
P01 | Heartbeat Measurements on eScooters for Continuous Health Monitoring | Prof. Dr. rer. nat. Dipl.-Ing. Thomas M. Deserno | Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School |
P02 | Identification of risk factors for postoperative acute kidney injury after non-cardiac surgery | PD Dr. med. Thomas Stüber | Department of Nephrology and Hypertension, Hannover Medical School Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and MHH, Hannover Medical School |
P03 | Delineating immune escape mechanisms in acute myeloid leukemia through single-cell analyses | Prof. Dr. med. Michael Heuser, MD | Pediatric Hematology and Oncology, Hannover Medical School Division of Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School |
P04 | Ambulatory assessment of online shopping activities in patients with compulsive buying-shopping disorder | Prof. Dr. med. Dr. phil. Astrid Müller | Faculty III - Media, Information and Design, Hannover University of Applied Sciences and Arts |
P06 | Development of a bioinformatics tool to predict clinical responses to CFTR modulator therapy by integrating microbial metagenomics, inflammatory cell transcriptomics, and secretomics | Prof. Dr. med. Anna-Maria Dittrich | Research Core Unit Genomics, Hannover Medical School |
P07 | Towards AI-based registration for advanced functional lung imaging | Prof. Dr. med. Jens Vogel-Claussen | |
P08 | Unsupervised identification of prognostic cell type signatures for CNS infiltration in ALL | Prof. Dr. med. Martin Stanulla, MD | German Center for Lung Research, Hannover Medical School |
P09 | Inter-hospital Transfer for Endovascular Treatment in Acute Stroke Care using the Smart Application "VIZ" | PD Dr. med. Hans Worthmann | Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and MHH |
P10 | Characterization of Ambulatory Blood Pressure Monitoring (ABPM) Profiles Using Data Mining and Machine Learning in Healthy and Diseased Children | Prof. Dr. med. Anette Melk, PhD Prof. Dr. Steffen Oeltze-Jafra Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School | Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg |
P11 | AI-based image analysis in pediatric echocardiography to improve the monitoring of relevant parameters in children with pulmonary hypertension | Dr. Mohamed Yaseen Jabarulla
Dr. med. Theodor Uden Pediatric Cardiology and Pediatric Intensive Care Medicine | - |
P12 | Is blended treatment using a web app-based therapy for mental disorders following life-threatening cardiac events more effective than non-blended treatment? | Prof. Dr. med. Kai G. Kahl, MD | Faculty IV, Department of Computer Science, Hanover University of Applied Sciences and Arts |
Project Title | Project Management | Collaboration partners |
| P01 - (Semi-)Automated procedures to find arguments for bioethical analyses | Prof. Dr. Sabine Salloch Institute of Ethics, History and Philosophy of Medicine | Institute for Information Systems Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P02 - Tracking fake papers in scientific journals | Prof. Dr. Roland Seifert Institute of Pharmacology, Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School |
P03 - Deciphering the long-term consequences of HCV infection after viral elimination (Long-HepC) using omics integration | Prof. Dr. Markus Cornberg Centre for Individualised Infection Medicine (CiiM); | Peter L. Reichertz Institute for Medical Informatics of the Technical University of Braunschweig and the Hannover Medical School |
| P04 - Development and Evaluation of an App to Support Patients with Hereditary Breast and Ovarian Cancer Following Genetic Counseling | PD Dr. Anke K. Bergmann Department of Human Genetics, Hannover Medical School
Prof. Dr.-Ing. Steffen Oeltze-Jafra Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P05 - Predictive immune biomarkers in renal cancer: Comparing the immune landscape of tumors in native and transplanted (immunocompromised) kidneys | Prof. Dr. Jan Hinrich Bräsen Institute of Pathology | Technical University of Braunschweig; Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
P06 - Development of predictive models for postoperative renal failure in children following heart surgery using a heart-lung machine | PD Dr. Martin Böhne Paediatric Cardiology and Intensive Care Medicine, Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics at TU Braunschweig and Hannover Medical School |
| P07 - Development of Translational Scores for a Quantitative and Time-Dependent Assessment of Disease Severity in Patients | Prof. Dr. André Bleich Laboratory Animal Science, Hannover Medical School | Department of Pediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School |
P08 - Clinical evaluation of a web app-based therapy for mental disorders following life-threatening cardiac events | Prof. Dr. Kai G. Kahl Department of Psychiatry, Social Psychiatry, and Psychotherapy | Department of Cardiology and Angiology Department of Computer Science, Hanover University of Applied Sciences and Arts |
| P09 - Next-generation flow cytometry to quantify and characterize the leukemic stem cell population in acute myeloid leukemia | Dr. Dr. Adrian Schwarzer Hematology, Hemostasis, Oncology, and Stem Cell Transplantation | Peter L. Reichertz Institute for Medical Informatics Department of Pediatric Hematology, Hannover Medical School |
| P10 - Towards identifying genetic determinants of antibiotic resistance in clinical Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae isolates | Prof. Dr. Susanne Häußler Institute for Molecular Bacteriology, TWINCORE | Helmholtz Centre for Infection Research (HZI) |
Project Title | Project Management | Collaboration Partners |
P03 - Development of an AI-based algorithm to predict kidney injury in stem cell transplant patients | Dr. Gernot Beutel Hematology, Hemostasiology, Oncology, and Stem Cell Transplantation Hannover Medical School | Braunschweig University Hospital, Clinical Department of Nephrology, Rheumatology, and Hemodialysis, Prof. Dr. Jan T. Kielstein |
P06 - Next-generation flow cytometry to detect minimal residual disease in acute myeloid leukemia | Dr. Dr. Adrian Schwarzer Hematology, Hemostaseology, Oncology, and Stem Cell Transplantation Hannover Medical School | Peter L. Reichertz Institute of Medical Informatics |
P07 - The Inner Clock - Introduction and use of a smart communication tool to improve emergency care for stroke patients | PD Dr. Hans Worthmann Neurology, Neuroradiology Hannover Medical School | Hannover University of Applied Sciences and Arts, Peter L. Reichertz Institute of Medical Informatics |
P08 - Determination of reference values for regional ventilation from CT scans of the lungs | Prof. Dr. Hoen-oh Shin Diagnostic and Interventional Radiology Hannover Medical School | Fraunhofer MEVIS Institute for Digital Medicine, Bremen |
P09 - Web app-based prevention and treatment of adjustment disorder following life-threatening cardiac events – the “AD-support” study | Prof. Dr. Kai G Kahl / Dr. Ivo-Aleksander Heitland Psychiatry, Social Psychiatry, and Psychotherapy Hannover Medical School | Leibniz University Hannover, Institute for Information Systems and Management (ISMI) |
P10 - Reducing the socio-economic burden for rare disease patients using artificial intelligence (AI) | Prof. Dr. Annette Doris Wagner Kidney and Hypertension Diseases Hannover Medical School | University Hospital Marburg, Institute for Artificial Intelligence in Medicine, Ada Health GmbH |
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