Doctoral theses, Master's theses and Bachelor's theses
2021
Khalifa AA (Dr. med.): Digital image analysis of macrophage density in kidney transplant biopsies identifies patients at increased risk of functional loss.
Köpke, Nora (Dr. med.): The prognostic significance of CD95L expression for patients with primary supratentorial glioblastoma.
Mund EM (Dr. med.): Autopsy findings-based transplant pathology: investigation of discrepancies between clinical and postmortem diagnoses.
Petker, Larissa (M. Sc. Biomedicine): Detection of homologous recombination deficiency (HRD) and microsatellite instability (MSI) in archived tumor samples: Validation of a SNP array and NGS panel.
Sammouri R (Dr. med.): Digital immunotyping in pre-implantation and follow-up renal transplant biopsies to identify patients at increased risk for shorter graft survival.
2020
Abbetmeier Basse, Merle (Dr. med.): CNS invasion by meningiomas as a prognostic marker
Abraham LM (Dr. med. dent.): Retrospective evaluation of autopsy findings in patients with lymphoid neoplasms.
Lippmann T (Dr. med.): Fluorescence in situ hybridization in infection diagnostics on formalin-fixed tissue.
Persing, Sascha (Dr. med.): Detection of resistance-mediating mutations in metastases and in the blood of bronchial and breast cancer patients.
Salim, Mustafa (Dr. med.): Distribution, frequency and function of mutations in the TET2 gene in myeloid neoplasms
Schaumann, Nora Mareen (Dr. med.): Studies on interobserver concordance in the histological grading of lobular lesions of the breast
Schenk MK (Dr. med. dent.): Fluorescence in situ hybridization (FISH) for the investigation of growth receptor genes in salivary gland carcinomas.
Schulze W, Martin L (Dr. med.): Subtyping and analysis of the spatial distribution of macrophages and microglia in the tissue context of IDH1 (R132H) mutated glioblastomas.
Wehling J (Dr. med.): Comparative analysis of CRISTAL and paraffin-embedded samples for histological and molecular pathological analysis of human lung samples.
2019
Faisal Muhammad (PhD): Splice factor mutations in myeloid neoplasia: functional and clinical relevance
Grote, Isabel (M. Sc. Biochemistry): Establishment of mRNA-based translocation and mutation detection for bronchial carcinoma patients using next generation sequencing (NGS)
Westphal, Lina (M. Sc. Biomedicine): Influences of single nucleotide polymorphisms (SNPs) on incidence and functional aspects of hematologic neoplasms
2018
Stadler, Julia (Dr. med.): Investigations into the significance of a mutation in the calreticulin gene for the differential diagnosis and prognosis of patients with myeloproliferative neoplasia (MPN)
Vogtmann, Julia (B.Sc. Biochemistry): Investigations on the validity of monomorphic markers and the stability of established STR markers in microsatellite-instable colorectal carcinomas (MSI+CRC)
2017
Akbas, Ayla (Dr. med. dent.): Post-transplant lymphoproliferative diseases with naso- and oropharyngeal manifestation
Jödecke, Kai (B. Sc. Biology): Analysis of ESR1 exon 5 mutations and gene amplifications as possible resistance mechanisms to antihormonal therapy in bone marrow metastases of breast carcinoma
Luft, Angelika (M. Sc. Biomedicine): Genetic and epigenetic defects in triple-negative breast cancer
Sittig, Antonia (Dr. med. dent.): History of dentistry: meta-analysis of caries and tooth loss in Europe over the centuries
2016
Bartels, Stephan (Dr. rer. nat.): Analyzing the mutational landscape and clonal evolution in myeloid neoplasms using next generation sequencing
2015
Cramer, Lara (Dr. med. dent.): Meta-analysis of CT-examined Egyptian mummies with a focus on dental and jaw pathology
Eckhardt, Sören (Dr. med.): "Esophageal-tracheal combitube" as a means of securing the airway during anesthesia
Engelhardt, Bianca (Dr. med.): Thrombospondin-1 overexpression in the bone marrow of primary myelofibrosis
Könenkamp, Yvonne (Dr. med.): Proliferation activity of BRCA1-associated breast carcinomas
Meincke, Kaja (Master Biochemistry): Detection of Fusion Transcripts in Lung Cancer by Next-Generation Sequencing
Modde, Friedrich Karl Heinrich (Dr. med.): The von Willbrand factor-cleaving protease ADAMTS13 and other coagulation-relevant factors in the glomerular vascular bed in thrombotic microangiopathy
Salem, Johannes (Dr. med.): Aberrant expression of caspase 14 in urothelial carcinomas of the urinary bladder
Schmidt, Lars (Master Biomedicine - Master): Establishment and validation of an assay to detect Copy Number Variations (CNVs) in tumor biopsies via Next-Generation-Sequencing (NGS)
2014
Abbas, Mahmoud (Dr. med.): Molecular pathological studies of tumor angiogenesis in metastatic renal cell carcinoma
Freitag, Lukas (Dr. med.): Importance of the investigation of fetal, placental and maternal factors for the evaluation of intrauterine fetal death
Just, Sabrina (Bachelor Biology): Validation of sequence changes detected with next-generation sequencing using Sanger sequencing and pyrosequencing
Karch, Inga (Dr. rer. nat.): Role of E-cadherin inactivation in the development of human invasive lobular breast cancer
Kienzle, Vanessa (Bachelor Biology): Investigation of mRNA splicing defects in myeloproliferative neoplasms (MPN)
Mägel, Lavinia (Dr. med.): Characterization of human plexiform vasculopathy (in pulmonary arterial hypertension)
Noskowicz, Monika (Dr. med.): Studies on the expression and function of the endogenous temperature-sensitive p53 mutant E285K in human breast cancer cell lines
Rößler, Jessica (Dr. rer. nat.): Role of epigenetic instability in the transformation of human mammary epithelial cells
Scharenberg, Constance Xenia (Dr. med. dent.): Expression of Caspase 14 and Filaggrin in Oral Squamous Carcinoma
Scheurer, Elisa Kathleen (Dr. med. dent.): The functional relevance of ABCB1MDR1P-gp in the breast cancer cell line IPH-926 and in breast carcinoma
Seegers, Anna (Dr. med.): Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V61F mutation
Senft, Ellen Karin (Dr. med. dent.): Expression of p16, p53 and EGFR in salivary gland tumors is not associated with human papillomavirus infection
Thöle, Lena (Bachelor Biochemistry): Quantitative validation of pyrosequencing assays for hematopathologic diagnostics
2013
Anwar, Lukman Sumadi (MD/PhD): Aberrant DNA methylation at microRNA genes and imprinted loci in human hepatocellular carcinoma
Hauck, Gesa (Dr. med.): Myelofibrosis in Philadelphia chromosome-negative myeloproliferative neoplasms is associated with aberrant karyotypes
Pasedag, Thomas (Dr. med.): Clinical course and long-term results of neurosurgically treated insular brain tumors
Stempel, Markus (Bachelor of Biochemistry): Studies on DNA methylation of the snoRNA genes SNORD123, ACA59B and U70C in human tumor samples
Tiede, Christina (Dr. med. dent.): Risk factors and prognosis of T-cell posttransplant lymphoproliferative disorders: Reevaluation of 163 cases
2012
Agustian, Putri Andina (Dr. med.): Diminished met signaling in podocytes contributes to the development of podocytopenia in transplant glomerulopathy
Forstmeier, Vinzent (Dr. med.): ADAMTS13 is reduced as a marker of the contractile phenotype of vascular smooth muscle cells in benign nephrosclerosis
Knöner, Maximilian Wilhelm Horst (Dr. med.): Studies on the expression and prognostic significance of KAI/CD82 in gastric carcinoma
Meier, Sascha Pascal (B.Sc. Biochemistry): Systematic comparison of two protocols for the treatment of DNA with bisulfite regarding conversion efficiency and DNA degradation
Struckmeyer, Imke (Dr. med. dent.): Extraosseous minimally invasive transcanthal lateral approach for microsurgical extirpation of orbital tumors
2011
Franke, Christof (Bachelor of Biochemistry): Establishment of "high resolution melting" (HRM) analysis for the detection of DNA methylation and comparison with MSP, COBRA and pyrosequencing
Lübben, Verena (Bachelor Biochemistry): Investigations on DNA methylation patterns of microRNA genes in benign liver tumors
2010
Albat, Cord (Dr. rer. nat.): Aberrant DNA methylation of microRNA genes in preneoplastic liver cell damage and hepatocellular carcinomas
Dr. med.): Megakaryocytic expression of miR-10a, miR-126, miR-17-5p and miR-20a in Philadelphia chromosome-negative chronic myeloproliferative neoplasms
Frye, Bernd (Dr. med.): Vascularization in the bone marrow during imatinib therapy of chronic meyeloid leukemia
Pokorny, Juliane (Dr. med.): Studies on the mRNA expression of dlk and nm23-H1 in human myeloid neoplasms
Preußner, Ina (Dr. med.): Molecular markers of angiogenesis in primary myelofibrosis - Quantitative gene expression analyses of VEGF, the VEGF receptors -1 (Flt-1) and -2 (KDR), as well as hypoxia-inducible factor 1α (HIF-1α) and endostatin
Schubert, Victoria Franziska (Dr. med.): Arteriolar hyalinosis in renal transplant biopsies: prevalence and clinicopathological correlation
Winter, Melissa (Dr. med.): Gene expression study of CD9/motility-related protein-1, neutrophil elastase and a1-antitrypsin in primary myelofibrosis.
2009
Albrecht, David (Bachelor Biochemistry): Sensitivity and specificity of different assays for the detection of hypermethylation of the MGMT gene
Fischer, Sebastian (Bachelor Biochemistry): MicroRNA profile of basal and luminal human mammary epithelia
Prieß, Maren (Dr. med.): Pathogenetic significance of tissue transglutaminase in chronic graft injury
Theophile, Katharina (Dr. rer. nat.): Megakaryocytic apoptosis in primary myelofibrosis
Weidner, Jenny (Dipl. Biol.): Studies on DNA methylation in the O6-MGMT gene in human glioblastomas
2008
Christgen, Matthias (MD/PhD): Isolation and characterization of clonogenic human breast cancer cells
Neuse, Johanne Friederike (Dr. med.): Quantitative gene expression analysis of collagen types -1 and -3 as well as matrix metalloproteinases -13 and -14 in bone marrow cells of defined stages of chronic idiopathic myelofibrosis
2006
Brakensiek, Kai (Dr. rer. nat.): Studies on abberant DNA methylation in human myeloid neoplasms using high-resolution quantitative analysis methods
Höfner, Thomas (Dr. med.): Stimulation of blastic cell lines in vitro - expression analysis of differentiation-associated genes and comparative morphological studies
Loch, Gero Hendrik (Dr. med.): Expression analysis of fibrosis-associated genes in bone marrow cells of chronic idiopathic myelofibrosis
Müller, Mirco (Dipl. Biochem.): DNA methylation patterns of microRNA genes in breast carcinoma cells
Neusch, Michael (Dr. med.): Quantitative mRNA expression analysis of beta-catenin, FKBP51 and HSP-70.1 in bone marrow cells of chronic myeloproliferative diseases
2005
Buurman, Hilke (Dr. med.): Comparison of the amplification pattern of growth-regulating genes in intraductal and invasive breast carcinoma components
Dingemann, Jens (Dr. med.): Quantitative analysis of mRNA expression of the DNA methyltransferases DNMT-1, -3A and -3B in bone marrow biopsies from MDS patients
Jänisch, Stefanie (Dr. med.): Expression of P-glycoprotein in astrocytic and oligodendrolial tumor cells of human malignant gliomas
Jonigk, Danny David (Dr. med.): Epithelial microchimerism after kidney transplantation
Rauhut, Yvonne (Dr. med.): Quantitative gene expression analysis in paraffin-embedded bone marrow cells using laser microdissection - detection of light chain restriction in B-cell neoplasms
Römermann, Daniel (Dipl. Biochem.): Studies on hypomethylation of repetitive sequences of the human genome using PCR-based methods
Traub, Frank (MD/PhD): Profiling of Breast Cancer
Vrielmann, Rena (Dr. med.): Immunohistochemical detection of oncogenic viral proteins in tumors after kidney transplantation
2004
Kesselring, Christine (Dr. med.): Deletions of the chromosomal region 11p15.5 in microdissected invasive and non-invasive parts of mammary carcionomas
Müller, Imke G. (Dr. med.): Immunohistochemical detection and prognostic significance of CD40 and cytotoxic T lymphocytes in transplant kidneys with early rejection.
Serinsöz, Ebru (MD/PhD): Quantitative gene expression analysis in archival renal allograft biopsies after laser microdissection
Springmeyer, Natascha (Dr. med.): Discrepancy between clinical diagnosis and autopsy findings in perioperative deaths at Hannover Medical School before and after the introduction of a consent solution
Tessema, Mathewos (MD/PhD): Aberrant DNA methylation patterns in myelogenous leukemia
Wilke, Nadine (Dr. med.): Quantification of gene amplifications in laser-microdissected intraductal breast carcinomas: Correlation between gene amplifications and histologic grading according to the Van Nuys classification
2003
Domb, Stefanie (Dr. med.): Immunohistochemical investigation of p16INK4a expression and its prognostic significance in gastric carcinoma
Schlué, Jerome (Dr. med.): Pseudo-Gaucher cells in the bone marrow in chronic myeloid leukemia: Prognostic and differential diagnostic significance
2002
Aanesen, Jens Joakim (Dr. med.): Development of a clonality detection for intraductal epithelial proliferations of the breast using laser microdissection and PCR
Benten, Daniel (Dr. med.): Detection of chromosomal aberrations in anaplastic thyroid carcinomas using comparative genomic hybridization and fluorescence in situ hybridization and PCR
Bredt, Martin (Dr. med.): Comparative genomic hybridization and fluorescence in situ hybridization for the differentiation of multicentric origin and intrahepatic metastasis of hepatocellular carcinoma
Mengel, Michael (Dr. med.): Interlaboratory and interobserver reproducibility of immunohistochemical assessment of the Ki-67 labeling index in a large multicentre trial
2001
Varga, Sabine (Dr. med.): Techniques of molecular cytogenetics in the imaging of recurrent aberrations in hematologic neoplasms
von Wasielewski, Sabine (Dr. med.): Histology and Prognosis in Hodgkins's disease
2000
Baer-Henney, Stefanie (Dr. med.): Sea-blue histocytes in the bone marrow in chronic myeloid leukemia: significance for prognosis and differential diagnosis
1998
Kneitz, Hermann (Dr. med.): Proliferation-dependent binding of the transcription factor NF-Y to the CCAAT boxes of the topoisomerase IIa G promoter in human lymphocytes
Meliß, Rolf Rüdiger (Dr. med.): Frequency of clinical autopsies under the objection versus the consent solution at Hannover Medical School