Bone marrow register

In most cases, the diagnosis of disorders of the hematopoietic system includes a histological bone marrow examination. The Institute of Pathology at the MHH has particular expertise in the integrated histological and molecular pathological diagnosis of bone marrow diseases and is a leader in this field in Germany. Over decades, a bone marrow register has been built up that contains more than 200,000 diagnostic cases and cases from therapy studies that can be used for educational and scientific purposes.

The bone marrow registry is the reference institution for several nationwide studies concerning chronic myeloid leukemia, polycythemia rubra vera, essential thrombocythemia and other myeloproliferative neoplasms. Furthermore, several therapy studies on myelodysplastic syndromes are supervised in terms of reference pathology.

Since 2013, the Institute has been a reference institution in the newly founded "Myelodysplastic Syndrome Research Network" funded by German Cancer Aid. Research questions include the age-related failure of the hematopoietic stem cell, the remodeling of the stem cell niche in the bone marrow and clonal evolution.

Selected publications:

Lehmann U, Bartels S, Hasemeier B, Geffers R, Schlue J, Büsche G, Hussein K, Kreipe H. SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis. Blood. 2013 May 9;121(19):4011-2.

Buhr T, Hebeda K, Kaloutsi V, Porwit A, Van der Walt J, Kreipe H. European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from prefibrotic primary myelofibrosis. Haematologica. 2012 Mar;97(3):360-5.

Muth M, Büsche G, Bock O, Hussein K, Kreipe H. Aberrant proplatelet formation in chronic myeloproliferative neoplasms. Leuk Res. 2010 Nov;34(11):1424-9.

Hussein K, Bock O, Theophile K, von Neuhoff N, Buhr T, Schlué J, Büsche G, Kreipe H. JAK2(V617F) allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis. Exp Hematol. 2009 Oct;37(10):1186-1193

Hussein K, Bock O, Theophile K, Schlue J, Ballmaier M, Kröger N, Göhring G, Büsche G, Kreipe H. Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation. Blood. 2009 Feb 5;113(6):1391-2.

Theophile K, Hussein K, Kreipe H, Bock O. Expression profiling of apoptosis-related genes in megakaryocytes: BNIP3 is downregulated in primary myelofibrosis. Exp Hematol. 2008 Dec;36(12):1728-38.

Head: Prof. Dr. med. H. H. Kreipe; e-mail to: Kreipe.Hans@MH-Hannover.de

Collaborators: PD Dr. med. G. Büsche, PD Dr. med. K. Hussein, Dr. med. J. Schlue