AG Prof. Dr. A. Kispert

Research

Our research focuses on the genetic control mechanisms of vertebrate development using the mouse as a model organism. In particular, we want to better understand the cellular and molecular processes that are crucial for the development of organs such as the heart, lungs, inner ear and especially the kidney and ureter. Our work also aims to better understand congenital human diseases such as cardiac valve septal defects, urinary tract anomalies and hearing loss. To this end, we are developing mouse models for these diseases and deciphering the molecular changes associated with them. In the long term, this could provide the basis for the resumption of development programs for regenerative approaches in human diseases.

A major focus of our molecular work is the analysis of signaling pathways (including Hedgehog, Wnt, Bmp and Pdgf) and transcription factors of the T-box (Tbx) gene family and their integration into pattern formation and differentiation during organogenesis.

We utilize all techniques of modern cell and molecular biology as well as mouse embryological manipulations and transgenics and targeted gene disruption to gain insights into the mode of action of genes in vivo and in vitro.