More news on the homepage
Liver cancer remains a challenging disease despite new therapies. In order to find targeted treatment approaches, the analysis of genetic changes in the tumor is important. In a comprehensive study led by PD Dr. Anna Saborowski and Prof. Dr. Dr. Arndt Vogel, genomic data from over 2,000 patients with hepatocellular carcinoma (HCC) were evaluated - including the largest cohort to date with cHCC-CCA, a rare form of liver cancer that combines characteristics of two tumor types.
The molecular analysis showed that cHCC-CCA has significantly more frequent mutations in the IDH1 and FGFR2 genes - changes that already have therapeutic relevance in other types of cancer. This work, which includes patients from five genetic backgrounds, is the largest international cohort with genomic data on liver cancer to date. It shows that detailed genetic analysis not only opens up new therapeutic approaches, but also supports the diagnosis of complex tumors.
The study was conducted by Dr. Christoph Gerdes (first author) and others in cooperation with the Molecular Pathology Department (Dr. Stephan Bartels) under the direction of PD Dr. Anna Saborowski and Prof. Dr. Arndt Vogel and has been published in the journal ESMO Open: https: //www.esmoopen.com/article/S2059-7029(25)01918-0/fulltext