Bachelor's and Master's theses
We offer several places for Master's and Bachelor's theses.
Possible topics and the relevant contact persons:
Research area: Non-canonical cyclic nucleotides: cCMP and cUMP (contact: Dr. Sabine Wolter, e-mail)
- Analysis of proliferation inhibition in breast carcinoma cell lines, other cell lines or primary cells, investigation of the mechanism of action
- Identification of further cCMP- and cUMP-binding proteins using cNMP agaroses or biotin-cNMPs
- Studies on the newly identified cCMP- and cUMP-binding proteins, e.g. characterization of the binding of cCMP and cUMP to AKAPs
Research area: Function of cyclic nucleotides in infections/in the immune system (contact: Dr. Bastian Schirmer, e-mail)
- Characterization of the signal transduction of identified 3',5'-cUMP targets
- Metabolomic screening for cNMP effector signaling pathways in lymphocytes
- Screening for drugs that modulate the nucleotidyl cyclase activity of ExoY
- Analysis of the T-cell toxicity of the effector protein ExoY from P. aeruginosa
Research area: The histamine H4 receptor (contact: Prof. Dr. Detlef Neumann, e-mail)
- Production of permanent epithelial cell cultures for the investigation of H4R function.
- MS-based analysis of the change in the metabolome caused by histamine stimulation
- MS-based measurement of histamine and histamine metabolite concentrations: comparison of samples from healthy and diseased models
- Analysis of the function of the H4R on cells of the immune system involved in colitis or colon carcinoma
- Development of 3-dimensional in vitro models for the functional investigation of colitis and colon carcinoma
- Analysis of possible histamine receptor complexes: homo/hetero di/polymers
- Analysis of an interaction of histamine receptors with GIRK1/2
Research area: Function of phosphodiesterases/nucleases in viral infections (contact person: Dr. Lina Schütte, e-mail)
- Screening of relevant virus genomes for genes coding for PDE/nuclease homologs and production/purification of the corresponding enzymes
- Identification of optimal reaction conditions for PDEs/nucleases
- Kinetic characterization of the cNMP-hydrolytic activity of PDEs/nucleases
- Screening for active substances that modulate the cNMP-hydrolytic activity of PDEs/nucleases