is based on the results of controlled studies and provides the scientific basis for our medical decision-making. However, in order to conduct studies under the most "controlled" conditions possible, there [...] s should still be good at the time of the start of therapy. "Conducting studies under the most controlled conditions possible is important to ensure an objective assessment of the investigational medicinal

reads (e.g. Illumina) as well as long reads (e.g. Oxford Nanopore) and incorporates flexible quality control, trimming, mapping, various filters, and normalization. The pipeline is available on Github http [...] with us. The workflow is based on Seurat and performs all substantial steps of scRNA-seq quality control, data pre-processing, including filtering, normalization and scaling, as well as data analysis, including [...] March 2019 Establishment of single-cell RNA sequencing Joint operation of a Chromium™ Single Cell Controller from 10x Genomics by the central research institutes cell sorting and genomics. October 2018 A

Association of human FOS promoter variants with the occurrence of knee-osteoarthritis in a case control association study. Int J Mol Sci. 20: 1382. Welz B, Bikker R, Junemann J, Christmann M, Neumann K [...] Westphal A, Suwandi A, Grassl GA, Brand K, Chan AC, Föger N, Lee KH. (2018 ). Surface receptor Toso controls B cell-mediated regulation of T cell immunity. J Clin Invest. 128: 1820-1836. Jyotsana N, Sharma [...] Dittrich-Breiholz O, Huber R, Brand K. (2017 ). TNF phase III signaling in tolerant cells is tightly controlled by A20 and CYLD. Cell Signal. 37: 123-135. Frantzi M, Van Kessel KE, Zwarthoff EC, Marquez M, Rava

response and pathological autoimmunity. The focus is on regulatory T cells (Tregs) as the central control center of immune tolerance in the liver and intestine. We analyze how function, stability and antigen [...] and cell engineering Our goal is antigen-specific and precise immunomodulation that specifically controls pathogenic immune reactions without unnecessarily weakening protective immunity. To this end, we [...] for therapeutic purposes. These approaches are relevant for applications in autoimmunity, in the control of therapy-associated autoimmunity (irAEs) and in transplantation medicine. The work has a translational

Todd Kuiken (rehabilitation physician) and Gregory Dumanian (plastic surgeon) to improve prosthesis control. In a complex microsurgical procedure, a selected severed nerve in the amputation stump is redirected [...] socket and reinnervates them. This creates a new and additional "myosignal" that can be used to control the prosthesis. This also reduces the likelihood of painful neuromas developing (again), as the growth [...] Sensory feedback on the residual limb in particular is considered crucial for improving prosthetic control, reducing phantom pain and improving embodiment (body awareness). TSR surgery can be performed to

anaesthetic. Several small tissue samples are then taken from the abnormal findings under sonographic control. This procedure only takes a few minutes and is well tolerated. The puncture site is treated with

activities. The tasks include: Continuous development of the clinic's research structures Continuous controlling of the research budget Content design of the research website Support in third-party funding a

Request cards and study stickers must be used for orders to the laboratory. These are available at the control center of the Institute of Clinical Chemistry and Central Laboratory (Tel. 2515). In the case of

medically-occupationally oriented rehabilitation aftercare: long-term results of the randomized controlled multicenter study. Rehabilitation 2016; 55 (2): 108-114 Gottschling-Lang A, Franze M, Hoffmann [...] and health-related quality of life of healthy young men in summer time in Germany: A prospective controlled study. Appetite 2016; doi: 10.1016/j.appet.2016.12.030 Radhakrishnan S, Kohler F, Gutenbrunner [...] Effects of acupuncture on quality of life and pain in patients with osteoporosis-a pilot randomized controlled trial. Arch Osteoporos 2016; 11(1): 34 Schwarze M, Egen C, Gutenbrunner C, Schriek S. Early Workplace

processing of audiovisually presented speech in patients with schizophrenia compared to healthy control subjects. The accompanying animation shows the surface reconstruction of the human cerebral cortex [...] processing of audiovisually presented speech in patients with schizophrenia compared to healthy control subjects. The measurement of brain activity during speech perception in this experiment takes about