Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable [...] replantation: a. Regenerative ex-vivo medicine/tissue engineering/cell-based therapy strategies b. Ex-vivo tumor therapy (ex-vivo radiotherapy and high-dose chemotherapy) c. Ex-vivo immunotherapy (e.g. ex-vivo [...] treated ex vivo. In addition, the aforementioned ex-vivo therapy strategies are also established for use in allogeneic transplantations. A) As part of interdisciplinary projects, the above-mentioned ex-vivo

Haastert-Talini, K., Katsirntaki, K., Kankowski, S., Kaltenborn, A., von Lübken, F., Falk, C., Werlein, C., Jonigk, D., Ruhparwar, A., Wiegmann, B. (2025) . Military Med Res 12, 72. https://doi.org/10 [...] and Critical Opinion on Their Translational Impact. Ronchi, G., Ackva, C., Fregnan, F., Zen, F., Muratori, L., Crosio, A., Metzen, J., Haastert-Talini, K. (2025) Int. J. Mol. Sci. 2025, 26(3), 1214; doi: [...] Cells: A Two-Center Study. Huang, Z.*, Powell, R*, Kankowski, S., Philips, J.B., Haastert-Talini, K. Int. J. Mol. Sci. 2023, 24(6), 5366; doi: 10.3390/ijms24065366 In Vivo and In Vitro Evaluation of a Novel

Haas J.A., Xiao K., Fuchs M., Just A., Pich A., Perbellini F., Ius F., Ruhparwar A., Fiedler J., Weber N., Thum T. (2024) MiR-21 inhibition results in cardioprotective effects in human heart failure ex vivo [...] system, LMS provide a unique opportunity to study cardiac tissue in a controlled yet physiologically relevant environment. This platform allows for precise modulation of myocardial tissue at a macroscopic level [...] Jung M, Mitzka S, Weber N, Dendorfer A, Perbellini F, Thum T. (2022) Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model. Basic Res Cardiol. 117(1):63

, Just, A., Pich, A., Perbellini, F., Werlein, C., Ius, F., Ruhparwar, A., Fiedler, J., Weber, N., Thum, T. (2024) Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo. European [...] RNA-based therapeutics RNA molecules play a critical role in a wide range of biological processes, including the initiation and progression of diseases. As a result, RNA-based therapeutics have emerged [...] companies. A recent success is the acquisition of our RNA-based spin-off company Cardior Pharmaceuticals GmbH by Novo Nordisk (2024). Contact: XXXX Viereck, J., Bührke, A., Foinquinos, A., Chatterjee

and Critical Opinion on Their Translational Impact. Ronchi, G., Ackva, C., Fregnan, F., Zen, F., Muratori, L., Crosio, A., Metzen, J., Haastert-Talini, K. (2025). International Journal of Molecular Sciences [...] Transplantation and Vascular Surgery. The work is funded by a contract of the German Armed Forces (2022-2026). We have recently established a protocol for deriving human Schwann cells from human iPSCs and [...] towards a patient-specific application in peripheral nerve repair. Key publications: Gut microbiota regulates optic nerve fiber myelination. Ronchi, G., Pellegrino, D., El Soury, M., Amato, O., Gaia, F., Farzin

Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q, Yang T, Balakrishnan A, Steinbrück L, Srivaratharajan S, Manns MP, Schambach A, Grimm D, Bohne J , Sharma AD, Büning H, Ott M. Ex Vivo/In vivo Gene [...] S, Kopp J, Rovai A, Varnholt D, Wachs AS, Goyenvalle A, Aarstma-Rus A, Ott M, Tiede A, Langemeier J, Bohne J. Pathological mechanism and antisense oligonucleotide-mediated rescue of a non-coding variant [...] and Results in IL-21R-like Deficiency. J Clin Immunol. 2019 Feb;39(2):207-215. 5. Stalke A, Pfister ED, Baumann U, Eilers M, Schäffer V, Illig T, Auber B, Schlegelberger B, Brackmann R, Prokisch H, Krooss

Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable [...] Selected publications 1. Calabrese F, Schiavon M, Perissinotto E, Lunardi F, Marulli G, Di Gregorio G, Pezzuto F, Vuljan S, Forin E, Wiegmann B, Jonigk D, MD, Warnecke G, Rea F; Organ Care System Lung resulted [...] Sommer W, Ius F, Kunze C, Gottlieb J, Varela A, Haverich A. Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study

Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR, Cantz T, Horscroft N, Balakrishnan A, Chevessier [...] Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q, Yang T, Balakrishnan A, Steinbruck L, Srivaratharajan S, Manns MP, Schambach A, Grimm D, Bohne J, Sharma AD , Buning H, Ott M. Ex Vivo/In vivo Gene [...] s (selected) Markovic J, Li R, Khanal R, Peng Q, Mobus S, Yuan Q, Engel B, Taubert R, Vondran FWR, Bantel H, Singh MK, Cantz T, Buning H, Wedemeyer H, Ott M, Balakrishnan A, Sharma AD . Identification

P, Herrmann A, Lotz J, Mengel M, Schwarz A: A blue kidney-chronic renal failure as a consequence of siderosis in paroxysmal nocturnal hemoglobinuria? Clin Nephrol 2006; 66(3): 210-3 Länger F, von Wasielewski [...] neutropenia. Nat Med 2006; 12(10): 1191-7 Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter P: High Resolution Genomic Profiling Reveals Association [...] V, Debertin A, Braun A, Walles T, Traub F, Pabst R: Density of dendritic cells in the human tracheal mucosa is age dependent and site specific. Thorax. 2006; 61(11): 986-91 von Wasielewski R, Klopper K

Cornelius A, Albanese M, Tagawa T, Chen YA, Krönke N , Eiz-Vesper B, Lienenklaus S, Bleich A, Theobald SJ, Schneider A, Ganser A, von Kaisenberg C, Zeidler R, Hammerschmidt W, Feuerhake F , Stripecke R. Spa [...] Cancer. 2019; 58(3): 175-185 Christians A , Adel-Horowski A, Banan R , Lehmann U , Bartels S , Behling F, Barrantes-Freer A, Stadelmann C, Rohde V, Stockhammer F, Hartmann C . The prognostic role of IDH [...] M, Mundhenke C, Nitz U, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Wenz F, Witzel I, Wöckel A. AGO Recommendations for the Diagnosis