2019 High-throughput methods and stem cell technology support the search for CFTR modulators The genetic lung disease cystic fibrosis cannot yet be cured. Since November 2015, the first therapy with CFTR [...] disease-specific induced pluripotent stem cells (iPSCs) in a high-throughput process. Until now, the genetic lung disease cystic fibrosis has been considered incurable; for a long time, only symptomatic treatment [...] is based on the use of induced pluripotent stem cells (iPSCs), which are obtained by reprogramming human somatic cells. These cells can be multiplied almost indefinitely in the laboratory and then differentiated

Degrees Doctoral Degree Institute of Biomedical Ethics and History of Medicine, Faculty of Medicine, University of Zürich, Switzerland, May 2015 Dissertation Title: “Organ Selling, Human Dignity and its Violation: [...] for the Humanities and Social Sciences). Associate researcher at the Department of Philosophy, University of Calgary, AB, Canada, November 2015 until December 2017. Research assistant in “Human Dignity [...] Caregivers’ Perspective on Biomarkers with Laypersons’ Attitudes towards Genetic Testing of Dementia Prediction”. New Genetics and Society . 39(1): 52-79. doi: 10.1080/14636778.2019.1637719 Alpinar-Sencan

research projects: Molecular biology of breast cancer Molecular genetics of ovarian cancer Molecular genetics of endometrial cancer Genetic epidemiology of cervical cancer Radiation sensitivity and DNA repair [...] biology or life sciences Intramural collaborations: Clinics of Radiation Oncology Institute of Legal Medicine Institute of Experimental Hematology Funding: Bruno and Helene Jöster Foundation Claudia von

caused by viruses, fungi and bacteria. A research team led by Dr Anna Christina Dragon from the Institute of Transfusion Medicine and Transplant Engineering at Hannover Medical School (MHH) is now developing [...] rejection," explains the young scientist. The structures on the surface of the body cells, the so-called human leukocyte antigens (HLA), are decisive for this. Based on these tissue characteristics, our immune [...] immune cells of the patient – the so-called T cells – which we convert into killer cells through genetic modification so that they precisely eliminate the responsible B cells that would otherwise produce

Status: 11 February 2021 On average, a human being consists of about 30 trillion body cells - and just as many bacteria. Without them, we would not be able to live. Not only in the intestine, on our skin [...] the renowned journal Biofilms and Microbiomes. Microorganisms form a community "Until recently, the human lower respiratory tract was considered sterile," explains Professor Tümmler. Therefore, most studies [...] assign it correctly. "The respective secretion samples contained only a few billionths of a gram of genetic material and about 90 per cent of that came from the children and only ten per cent from the mic

Associate at the Institute of Neuroanatomy and Cell Biology, Hannover Medical School 2000–2002 Ph.D. at the Clinical Department of Neurosurgery, Hannover Medical School, and the Institute of Pharmacology [...] Düsseldorf (Intermediate Examination) Academic Career 2011 – present: Research Group Leader at the Institute of Neuroanatomy and Cell Biology, Hannover Medical School July 2005–October 2005: Visiting Scientist [...] Pharmacy, and Toxicology at the University of Veterinary Medicine Hannover. Research Associate at the Institute of Anatomy II, University Hospital of Heinrich Heine University Düsseldorf Additional Qualifications

Principal investigator PD Dr. Jens Bohne Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone +49 511 532 4307 Departmental Secretary [...] l RNA expression. On the cellular side we are interested in non-coding mutations causing various human diseases. Both areas follow our central idea: A deeper knowledge of both viral gene expression and [...] rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B. PLoS Genet. 2020 Apr 8;16(4):e1008690. 3. Krooss SA, Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q

strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining [...] alleles with low stimulatory potential for the potential transplant recipient. Together with further "genetic engineering" in the context of ex vivo perfusion, it is thus possible to select or generate a xenograft

Jonathan Lühmann GERMANY Luehmann.Jonathan @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Optical Mapping to detect structural genomic variants in cancer Jonathan was class [...] Thum / Dr. Christian Bär (IMTTS) Project: Screening and validation of natural compound libraries in human iPSC-cardiomyocytes for the treatment of Fabry disease Final exam June 2024 Bushra Khan INDIA khan [...] Sommer @ item.fraunhofer.de Supervisors: Prof. Dr. Armin Braun / Dr. Katherina Sewald (Fraunhofer Institute ITEM) Project: Immune-related mechanisms of IL-2-induced skin rash and lung toxicity Final exam

23.09.2022 Li-Fraumeni syndrome (LFS) is a rare genetic disorder associated with a greatly increased risk of various types of cancer. The genetic defect can lead to multiple occurrences of malignant tumors [...] LFS-CPS@mh-hannover.de or by phone at (0511) 532-9037. Whole-body MRI examinations are performed at the Institute for Diagnostic and Interventional Radiology (Director: Professor Dr. Frank Wacker), where the contact [...] Radiology. Li-Fraumeni syndrome is one of the cancer disposition syndromes and is caused by a hereditary genetic alteration in the TP53 gene. Professor Kratz has been working on Li-Fraumeni syndrome for many years