is to vascularize organoids and to produce functional kidney tissue from human stem cells. We use zebrafish embryos with genetic markers for renal cells, macrophages and endothelium and LSM microscopy to [...] mechanisms of vasculogenesis. In parallel, we are studying new vessel formation in human renal organoids. We have discovered that human macrophages strongly influence vascularization and endothelial differentiation [...] hypothesis is that impaired signal transduction of VEGF is responsible for aging and that targeted genetic manipulation can arrest these aging and dedifferentiation processes. Our second research project

clinics and institutes are also on board. These include experts from haematology, nephrology, gastroenterology, immunology, nuclear medicine, pathology, plastic surgery, paediatrics, human genetics and radiology

Interventional Radiology Institute of Human Genetics Institute for Radiotherapy and Special Oncology Comprehensive Cancer Center (CCC) Hannover Center for Clinical Trials Clinic for Pediatric Pneumology, A [...] insights into the causes and course of diseases. Cooperating institutes and departments at the MHH Institutes and departments Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover [...] collection and cross-institutional exchange of medical data for health care and research. Research Research also benefits directly from the possibilities of exchanging data across institutions. On the one hand

with fatal outcome. Clin Genet 2009; 76(5): 493-5 Chevillotte M, Landwehr S, Linta L, Frascaroli G, Lüske A, Buser C, Mertens T, von Einem J: Major tegument protein pp65 of human cytomegalovirus is required [...] Schlegelberger B, Kreipe H, Lehmann U: Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer. J Pathol 2009; 217(5): 620-32 [...] Kreipe H, Schlegelberger B: Histopathological criteria and selection algorithms for BRCA1 genetic testing. Cancer Genet Cytogenet 2009; 189(2): 105-11 Ganzenmueller T, Henke-Gendo C, Schlue J, Wedemeyer J,

Pediatric Muscle Consultation, Cardiology, Orthopedics, Pneumology, Immunology and Rheumatology, Human Genetics, Physical Medicine and Rehabilitation, Siloah Clinic (Pneumology), Children's Hospital on the [...] ALS and muscle consultation Head: Prof. Dr. med. S. Petri The institute founded by the Society for Muscular Dystrophy (DGM) certified Neuromuscular Center of the MHH (Hannover Medical School) is an in [...] appears appropriate and is desired. In addition to clinical assessment, extensive laboratory tests, genetic tests and modern imaging and neurophysiological procedures in laboratories with many years of experience

Hartmann, Chair of Neuropathology, Institute of Pathology, MHH Brain tumor families and their genetic changes, Prof. Dr. med. Ruthild Weber, Institute of Human Genetics The CATNON study - Do we need to rethink [...] the exciting program: MRI for cranial tumors - a program for all entities? Dr. med. Peter Raab, Institute of Diagnostic and Interventional Neuroradiology, MHH Paraneoplastic neurological syndromes, Dr.

updates ESMO treatment guidelines for biliary carcinoma Prof. Dr. Arndt Vogel has illustrated the genetic changes in bile duct cancer for which targeted therapies are already available. Photo: Maike Isfort [...] ducts and gallbladder. BCTs are rare and account for less than one percent of malignant neoplasms in humans. Overall, BCT has a poor prognosis. Five years after diagnosis, only 10 to 20 percent of those affected [...] n from the European Medicines Agency (EMA). Breakthrough in molecular sequencing The search for genetic changes using molecular sequencing has led to significant successes in the treatment of cancer in

detection and prevention of risks associated with genetic cell modification and training of young scientists are important missions of our Institute. The Institute of Experimental Hematology (IEH) contributes [...] Science at the IEH The Institute of Experimental Hematology (IEH) investigates the biology of blood cell formation and function with a special focus on genetic cell modification as a new therapeutic modality [...] assessment of novel therapeutic approaches. The experimental scope of our institute ranges from investigation of basic mechanisms of genetic cell modification to implementation of translational projects designed

ducts and gallbladder. BCTs are rare and account for less than one percent of malignant neoplasms in humans. Overall, BCT have a poor prognosis. Five years after diagnosis, only 10 to 20 percent of those affected [...] n from the European Medicines Agency (EMA). Breakthrough in molecular sequencing The search for genetic alterations using molecular sequencing has led to significant successes in the treatment of cancer [...] for biliary tumours," Vogel points out. "Almost 40 per cent of patients with biliary tumours have genetic alterations that are potential targets for precision medicine and for which we now have targeted

/ Ms. Steinhage ENDOGEN Genetic disposition for endometrial cancer Study management: Molecular Gynecology Group of the Research Center ENDOMED Polymorphism, factors, genetic variability and predisposition [...] Inhibitors and Fulvestrant versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced, Unresectable or Metastatic Breast Cancer [...] first-line setting in patients with endocrine-sensitive PIK3CA-mutated hormone receptor-positive (HR), human epidermal growth factor receptor 2-negative (HER2), advanced breast cancer (ABC) Study conduct: Prof