Institute of Laboratory Animal Science and Central Animal Laboratory Welcome to the website of the Institute of Laboratory Animal Science and Central Animal Laboratory of the Hannover Medical School. Animal [...] impulses for this subject emanate. The Institute of Laboratory Animal Science and Central Animal Laboratory, one of the largest and most complex facilities or Institutions for laboratory animal science in Europe [...] indispensable prerequisite for successful biomedical research. Research The close links between the Institute and the Central Animal Laboratory enable biomedical research to be combined with laboratory animal

and modes of therapy in human beings it should be human and not veterinarian pathologists who perform the histologic analysis. Whereas human pathology is experienced with human diseases generally there [...] including immunohistochemistry, which are done in the Institute of Pathology. Smaller series of immunohistochemistry are prepared by the group in the Institute of Pathology, larger series will require technical

temperature-sensitive p53 mutant E285K in human breast cancer cell lines Rößler, Jessica (Dr. rer. nat.): Role of epigenetic instability in the transformation of human mammary epithelial cells Scharenberg, [...] Studies on DNA methylation in the O6-MGMT gene in human glioblastomas 2008 Christgen, Matthias (MD/PhD): Isolation and characterization of clonogenic human breast cancer cells Neuse, Johanne Friederike (Dr [...] of CRISTAL and paraffin-embedded samples for histological and molecular pathological analysis of human lung samples. 2019 Faisal Muhammad (PhD): Splice factor mutations in myeloid neoplasia: functional

A. Pich (Dept. of Institute of Toxicology, MHH). We were able to identify several candidate genes that play a role in the apoptosis pathway, including Bcl2. In both murine and human cells, we confirmed [...] developing new ones. We use cell culture and mouse models as well as viral gene transfer for the genetic manipulation of hematopoietic cells. This includes the overexpression of genes and miRNAs as well

discourses in human and veterinary medicine about the end of life care for humans and pets and some consequences for the relations between medical and animal ethics Further links Institute for Animal Hygiene [...] Dying like a dog? Convergences and divergences in the human and veterinary ethical discourse on the end of life of humans and pets and consequences for the relationship between medical and animal ethics

Infektiologie und Endokrinologie ‘Generation of multicellular human liver microtissue models using organoid-derived and direct reprogrammed human hepatocyte-like cells’ Fawaz Ahmad Saleh from the Department [...] a scalable bioreactor platform to generate human iPSC-derived hematopoietic cell types for regenerative applications’ Ana-Maria Zamfirescu from the Institute of Cell Biochemistry ‘The stem cell niche as [...] high-throughput screening in an in vitro model of Parkinson´s disease' Abhishek Chiyyeadu from the Institute of Experimental Hematology ‘Antibody-based strategies for infections, cancer and regenerative medicine’

center, we work closely with our colleagues in pediatric pneumology, hematology-oncology and human genetics. This also includes an excellent transition of our adolescent patients from pediatric to adult

biological heart support system. So-called induced pluripotent stem cells (iPS cells) from genetically reprogrammed human tissue cells can be used to produce heart muscle cells. These will now form the basic

support system. With the help of so-called induced pluripotent stem cells (iPS cells) from genetically reprogrammed human tissue cells, heart muscle cells can be produced. These are now to form the basic building

Whether such cells also exist in the human lung remained controversial in science. Now, a research team led by Professor Dr. Christian Mühlfeld, acting head of the Institute of Functional and Applied Anatomy [...] sections from healthy, fibrotic or damaged (emphysematous) human lung tissue provided by Professor Dr. Danny Jonigk's team from the MHH-Institute of Pathology. Dr. Julia Schipke used various markers to highlight [...] in the human lung and filled an important gap in lung research," Professor Mühlfeld is pleased to say. The method of correlative microscopy, which has been further developed in his institute, of first