with light of a suitable wavelength. In the small animal model, questions can be linked to luminescence in a variety of ways: Bacteria, cells and animals can be genetically engineered to express luciferases [...] Limitations: Low tissue penetration of light, low resolution Back to the homepage of the Central Animal Laboratory

influence on the pathophysiology of the respective disease, are not yet fully understood. We use animal models to better understand the complex interaction of DBS with the neuronal functional loops of [...] and thus further improve this treatment method. It is crucial for the experimental studies that the animal model used reflects the Clinical Department and pathophysiology of the human disease and that the [...] correspond to those of humans in critical aspects. In a translational approach, we are investigating animal models for movement disorders and neuropsychiatric diseases the functional effects of DBS at the

made to provide animal organs for human transplant patients. Efforts to transplant organs from different species are referred to as xenotransplantation. Technically, the transfer of animal tissue or organs [...] enabled to live a long and pain-free life through the safe provision of a fully functional and healthy animal donor organ is absolutely essential and has therefore become the declared goal of our working group [...] projects is the preparation of preclinical porcine xenogeneic lung transplantation studies in the large animal model. Against this background, we are currently focusing on the following research priorities: 1)

storage. The center's own animal husbandry area is operated in close coordination with the central animal laboratory (ZTL) of the MHH and is used for temporary animal husbandry. Animals from the center are [...] tion hybrid system for integrated positron emission tomography and computer tomography in small animals. In the coupled multimodal system, PET and CT components can either be docked or operated separately

harmful to the animals. Scientific studies are always designed in such a way that our animals do not have to lose their lives or suffer unnecessarily. We are also developing alternatives to animal experiments [...] for new antibiotics. The axolotl could also offer solutions in the search for new antibiotics. The animals produce so-called antimicrobial peptides to defend themselves against pathogens. These are currently [...] in promoting translational research and linking biomedical research with species conservation and animal welfare. In this way, we want to make a contribution to sustainability in research and development

you will find an overview of all the services offered by the Institute of Laboratory Animal Science and Central Animal Laboratory

restoration of the beta cell function by regaining normoglycaemia in an infiltration-free pancreas. Animal models of human T1DM and T2DM are of particular importance in diabetes research to systematically [...] pancreatic samples were used to correlate the pathophysiological findings observed especially in this animal model in the context of similarities to the human situation under age-matched non-diabetic and diabetic [...] manifestation. This is important for a potential transfer of diabetes prevention strategies developed in animal models to humans after disease onset. The immune cell composition and the cytokine pattern of the

GMP-compliant large scale animal serum-free human mesenchymal stem cell (MSC) propagation Main tasks Work Package 7 - Advancing the processes for primary human MSC expansion: GMP-grade, animal serum-free and safe [...] tissues with superior efficiency adapted to TECHNOBEAT requirements - Providing fully characterized, animal serum-free MSCs of highest quality for advanced µ-tissue engineering and transplantation - Elucidating

Basic.Marijana @ mh-hannover.de Small animal imaging Dr. Martin Meier (MRI, µCT,FMT, ultrasound) +49 511 532-3949 Meier.Martin @ mh-hannover.de Laboratory animal pathology Dr. Silke Glage +49 511 532-8492 [...] Contact person Education Animal keeper Ziegowski, Christa +49 511 532-3756 Ziegowski.Christa @ mh-hannover.de Teaching and specialist events, further training Simone Schubert Martinez +49 511 532-6568

view to standardizing small animal imaging methods. In addition, the work focuses on the special handling of animals for imaging and the economic management of the small animal imaging center. Calibration [...] Meier working group Small animal imaging has established itself as an important tool in preclinical research. Nevertheless, the results of non-invasive imaging are often disappointing due to a suboptimal [...] Sep-Oct;25(5):738-43. doi: 10.5301/jn.5000053. PubMed PMID: 22180224. Back to the homepage of the Central Animal Laboratory