2014) Vera Kreuzer: The influence of the hypoxia-inducible molecule adenosine and its receptors A2A and A2B on placental processes (Dr. med., Hanover, 2014) May-Britt Heidrich: Preeclampsia and cardiovascular [...] complicated pregnancy outcomes. ► Pathomechanisms of endometriosis related to infertility using a 3D organ-on-a-chip model ► Age-related decidualization defects of endometrial stromal cells in women with advanced [...] and counseling behavior (Dr. med., Hanover, 2018) Akin Sarisin: The influence of adenosine and the A2B adenosine receptor on trophoblastic and endothelial functions during placental development (Dr. med

recombinant antibodies that show a broad neutralizing effect not only against SARS-CoV-2 but also against related bat coronaviruses that could, in theory, serve as a starting point of a new zoonis - after all, [...] long term, new therapies against SARS-CoV-2 and related corona viruses are expected to be developed in this way. SARS-CoV-2 vaccine / Development of a SARS-CoV-2 vaccine Project leader: Prof. Dr. Reinhold [...] for a surface protein of SARS-CoV-2 has been inserted. A special feature of Modified-Vaccinia-Ankara-Virus: it infects cells but cannot replicate. The immune system reacts nonetheless and forms a protective

emerged as a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is the main entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) regulating host cell infection. ACE2 is known [...] enzyme 2 (ACE2) plays a crucial role in regulating the entry of the SARS-CoV-2 particles into the host cells. In this project, we aim to investigate the non-coding RNAs which regulate SARS-CoV-2 infection [...] cardiomyocytes. We identified a few miRNAs that can target ACE2 based on in-silico analysis. Furthermore, we successfully demonstrated that miR-200c can inhibit both Ace2 mRNA and Ace2 protein levels in rat primary

interact is being investigated. As far as is known, a decrease in [Ca2+]i , as well as the activation of p38 MAPK (isoform a/b) and the transcription factor MEF2C, causes the gene expression of the fast fiber [...] which leads to muscle weakness and a tendency to fall. Scientific questions: 1) Studies on the physiological function of MAPK-activated protein kinases 2 and 2 (MK2/3) in the skellet muscle and heart of [...] develop in a complex differentiation process from mononuclear precursor cells, the myoblasts. The adult skeletal muscle cells (myotubes) consist of various muscle fibers. They are characterized by a pronounced

Projects TRPV2 Immune cells and the nervous system Expression and physiological significance of TRPV2 in human/mouse/rat immune cells with a focus on macrophages and mast cells Role of TRPV2 in viral infection [...] Differentiation of TRPV2-KO macrophages from human pluripotent stem cells Prof. Dr. Abel Viejo Borbolla, Institute of Virology, MHH: TRPV1 and -2 as receptors for herpex simplex virus 1 and 2 Dr. Jörg Isensee [...] Yarov-Yarovoy V. Leffler A, Moiseenkova-Bell VY. (2022) Structural insights into TRPV2 activation by small molecules. Nat. commun. 28;13(1). Bracke, F., Frieling, H., and Leffler, A. (2022). Antidepressants

the case of a positive SARS-CoV-2 PCR and/or a positive antibody test and typical symptoms noticed in the past. Prior to their infection, athletes must have regularly practiced sports with a training volume [...] COVID-19 in elite sport - A multicenter cohort study Clarification of recommendations for returning to sport after a Covid-19 infection The current coronavirus pandemic is already one of the biggest global [...] represents an extreme challenge not only for healthcare systems but for society as a whole. An infection with SARS-CoV-2 is largely associated with few to no symptoms, but can also have serious or even fatal

factor receptor-2 (FGFR2). In about 15 percent of patients with ICC, FGFR2 is fused, so to speak, with other genes due to a genetic malformation. These fusion rearrangements lead to a permanent activation [...] FGFR2," explains Dr. Saborowski. Such FGFR2 inhibitors have already been approved in the USA for ICC patients with FGFR2 fusion, for example, and the European regulatory authority has also given a positive [...] clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited extent, those affected often have a poor prognosis. For some

deficiency disease, 14 had a combined immunodeficiency, 16 had a genetic disorder of immune regulation, 6 had a granulocyte defect, 3 had a disorder of innate immunity and 2 had bone marrow failure. Ten [...] kinderimmunologie.de/neuartiges-Coronavirus Information on SARS-CoV2 and COVID-19 Status of the information: 02.11.2020 The SARS-CoV-2 pandemic is a very dynamic event. Recommendations and instructions from the [...] do not have a recognizably increased risk of becoming seriously ill from SARS-CoV-2 Patients with immunodeficiency who have at least one risk factor for becoming seriously ill from SARS-CoV-2. The known

interchange, continue on the A37 towards Hannover. From Dortmund or Berlin on the A2 to the Hannover-Buchholz interchange, continue on the A37 towards Hannover. Take the A37 or the Messeschnellweg to the [...] Hochschule By car From Kassel , take the A7 to the Hannover-Süd interchange, continue on the A37 towards Hannover. The A37 merges into the Messeschnellweg. From Hamburg on the A7 to the Hannover-Kirchhorst interchange [...] streetcars Line 123 from Peiner Str. (U 1 / 2 / 8) in the direction of Buchholz (U 3 / 7) or vice versa; stop Medizinische Hochschule Line 124 from Am Brabrinke (U 1 / 2) in the direction of Misburg or vice versa;

interchange, continue on the A37 towards Hannover. From Dortmund or Berlin on the A2 to the Hannover-Buchholz interchange, continue on the A37 towards Hannover. Take the A37 or the Messeschnellweg to the [...] Hochschule By car From Kassel , take the A7 to the Hannover-Süd interchange, continue on the A37 towards Hannover. The A37 merges into the Messeschnellweg. From Hamburg on the A7 to the Hannover-Kirchhorst interchange [...] streetcars Line 123 from Peiner Str. (U 1 / 2 / 8) in the direction of Buchholz (U 3 / 7) or vice versa; stop Medizinische Hochschule Line 124 from Am Brabrinke (U 1 / 2) in the direction of Misburg or vice versa;