All good things come in threes! The third issue of the ZKS newsletter takes a look at the updated Declaration of Helsinki (DOH) and the new ICH-GCP E6 R3 guideline, which comes into effect on July 23, 2025. Studies in focus: LFS-Metformin, G-LACC, MOLIVO-1, CARAML, and RESOLVE. You'll find this and much more in the new SPOTLIGHT. Enjoy reading!