Research Our group aims at a detailed characterization of the enzyme UDP-glucose pyrophosphorylase (UGP) , a candidate drug target, from pathogenic species and the human host to identify structural and/or [...] human (Homo sapiens). PDB IDs: 4M2A , 8F73 and 4R7P. Images generated with UCSF ChimeraX. Schemes of organisms from Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3 [...] and/or mechanistic differences that would allow the development of specific inhibitors targeting UGP as a novel anti-infective drug target. We have previously studied UGP from the protozoan parasite Leishmania

(Dr. med.) supervisor: PD Dr. Ott, Abt. Gastroenterology a. Hepatology, OE 6810, project: Safety and efficacy of hepatocyte transplantation in a rabbit model of hereditable hypercholesterolemia Final exam [...] Skokowa RUSSIA supervisor: Prof.Dr. R. E. Schmidt, Clinical Immunology, OE 6830, project: C5a anaphylatoxin is a major regulator of FcyRs on alveolar macrophages in immune complex induced lung injury Final

1186/s13054-021-03584-8. PMID: 33931122 Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk H, Hegermann J, Beverly-Staggs L, Hidalgo-Gonzalez A, Little MH, Drummond IA. Autonomous Calcium Signaling in Human [...] print. PMID: 33911000 Etzrodt V, Idowu TO, Schenk H, Seeliger B, Prasse A, Thamm K, Pape T, Müller-Deile J, van Meurs M, Thum T, Garg A, Geffers R, Stahl K, Parikh SM, Haller H, David S. Role of endothelial [...] Bräsen JH, Haller H, Schiffer M. Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep. 2019 Nov 27;9(1):17718. doi: 10.1038/s41598-019-54058-5. PMID: 31776394 Stahl

without affecting the recipient's immune system. Our generated HLA-A*02-specific CAR Tregs approach is currently being evaluated in a phase I/II clinical trial. Further Information Publications You can [...] of organs available. Despite the advent of novel immunosuppressants, chronic organ rejection remains a challenge. Maintenance therapy is mandatory after organ transplantations. Immunosuppressive drugs are [...] does not interfere with the immune system and protects the transplanted organs from rejection. It is a promising and affordable way to overcome the problems of immunosuppression, its severe side effects

aster: 4 mm DIN A5 Broschüre (148 x 210 mm) 10 Spalten, Spaltenbreite 8,5 mm, Stegbreite 4 mm Ränder: Oben 9 mm, Unten 13 mm, Innen 19 mm, Außen 8 mm Grundlinienraster: 4 mm 1/3 DIN A4 Broschüre (99 x [...] und Anordnung von Bildern regelt. Schriftgrößen und Satzangaben finden Sie im Kapitel Schrift. DIN A4 Broschüre (210 x 297 mm) 12 Spalten, Spaltenbreite 10 mm, Stegbreite 5 mm Ränder: Oben 9 mm, Unten [...] Stegbreite 4 mm Ränder: Oben 9 mm, Unten 13 mm, Innen 9 mm, Außen 6 mm Grundlinienraster: 4 mm 1/3 DIN A4 Faltblatt (99 x 210 mm) 8 Spalten, Spaltenbreite 7 mm, Stegbreite 4 mm Ränder: Oben 9 mm, Unten 13

Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus, López-Dávila A.J., Weber N., Kraft, T., Matinmehr F ., Arias-Hidalgo M., Fernández J [...] 5;97(3):806-24. doi: 10.1016/j.bpj.2009.05.023. Seebohm B, Matinmehr F , Köhler J, Francino A, Navarro-Lopéz F, Perrot A, Ozcelik C, McKenna WJ, Brenner B, Kraft T. [...] Slow-Twitch Fibers, López-Dávila AJ, Chalovich JM, Zittrich S, Piep B, Matinmehr F , Málnási-Csizmadia A, Rauscher AÁ, Kraft T., Brenner B, Stehle R., Front Physiol. 2020 Mar 24;11:144. doi: 10.3389/fphys

induces synaptic plasticity in human cortical neurons. Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A. (2021) doi: 10.7554/eLife.63026. Technical report: surgical preparation of human [...] VM, Heiland DH, Galanis C, Lenz M, Zhang J, Neidert NN, El Rahal A, Vasilikos I, Kellmeyer P, Scheiwe C, Klingler JH, Fung C, Vlachos A, Beck J, Schnell O. Acta Neurochir (Wien). 2023 Jun;165(6):1461-1471 [...] synaptic transmission and plasticity in the human brain. Within this research focus we implemented a translational and interdisciplinary strategy to assess synaptic transmission and plasticity in the human

Tourette-Syndrome: Results from a Cerebrospinal Fluid Study. Front Neurol. 2019 Jul 4; 10:732. Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Muller-Vahl K, et al. Kynurenine is a cerebrospinal fluid biomarker [...] J Neuropathol Exp Neurol 2014 Jun;73(6):507-18. Sühs KW, Hein K, Sattler MB, Gorlitz A, Ciupka C, Scholz K, et al. A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis. Ann Neurol [...] infections. J Infect Dis 2019 Jun 5; 220(1):127-138. Sühs KW, Fairless R, Williams SK, Heine K, Cavalie A, Diem R. N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic

Projects Allosteric regulation of UDP-sugar pyrophosphorylases as a means to develop new anti-parasitic treatments UDP-sugar pyrophosphorylases play a central role in cellular carbohydrate biosynthesis. As metabolic [...] innate immune sensors as a means to control infection and inflammation The innate immune sensors activate interferon-driven antiviral responses upon recognition of PAMPs and serve as a rheostat for the metabolic [...] development of new drugs against protozoan parasites. The current project pursues the goal to obtain a comprehensive description of the allosteric mechanisms regulating UDP-sugar pyrophosphorylases in the

Spezialambulanzen Ambulanz für Vaskulitiden und Kollagenosen mit Nierenbeteiligung (u.a. ANCA-Vaskulitis, Lupusnephritis), IgA-Nephropathie, renale Amyloidose, Nierenerkrankung in der Schwangerschaft In dieser [...] (Granulomatose mit Polyangiitis, mikroskopische Polyangiitis) Renaler Lupus Erythematodes (SLE), und IgA Nephritis Checkliste zum Ambulanztermin Eine zum Termin aktuelle Überweisung vom Nierenfacharzt/Nephrologen