In cellular signal transduction, many different post-translational modifications play a very important, possibly even an essential role in signal transduction and the regulation of signal transmission processes. This applies to normal growth, differentiation and development processes, but in the case of deregulation can also trigger life-threatening diseases and promote their progression, e.g. in cancer and inflammatory processes.

Our research group deals with different areas of signal transduction processes, starting with the receptor, through various post-translational modifications of signaling proteins to their effects on gene expression. The focus is on phosphorylation, the conjugation of ubiquitin-like proteins of the SUMO group, as well as modifications with various metabolites (acetyl, lactyl and other acyl residues). We are investigating how these mostly transient protein modifications influence cellular processes and are also developing new methods for better visualization of the signaling processes in 2D and 3D cell culture models.