Transplantation biology

Allogeneic stem cell transplantation is a curative treatment for blood diseases such as acute leukemia, lymphoma and aplastic anemia. In malignant diseases, the curative effect of the therapy is based on the so-called "graft-versus-leukemia/lymphoma" (GvL) effect, which is mediated by transplanted immune cells from the stem cell donor. To date, however, this therapy is often associated with serious complications such as graft-versus-host disease (GvHD) and infections (including viral diseases).

Prof. Dr. med. Eva Mischak-Weissinger

Principle Investigator

Department of Hematology, Hemostaseology,
Oncology and Stem Cell Transplantation

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

E-mail

Projects

Studies on basic mechanisms and early detection of complications after allogeneic stem cell transplantation.

GvHD, relapses, viral infections

Development of allogeneic immunotherapies to strengthen the GvL effect.

e.g. Minor antigen-specific immunotherapy and generation of genetically modified T cells

Hematopoietic stem cell research, chimerism and PCR analyses.

Our investigations cover a broad spectrum of analyses, e.g:

Proteome analyses from body fluids
Tetramer monitoring of virus and transplantation antigens of specific immune reactions
special immunophenotyping
functional T-cell analyses