Research focus
AG Lachmann is a member of the Cluster of Excellence "RESIST", "REBIRTH - Research Center for Translational and Regenerative Medicine" and the "DZL - German Center for Lung Research". The working group is concerned with the development of novel, cell-based therapies for rare and common diseases with a focus on lung diseases. Different types of stem cells, such as induced pluripotent stem cells (iPSC), are used. The work combines translational stem cell research with the latest insights into the development of diseases, with a focus on infectious diseases. The resulting improved understanding will be translated into the development of innovative technologies for the generation of blood cells (with a focus on phagocytes) in order to develop sustainable, cell-based immunotherapies for patients.
Focus of research
The lab is a member of the Cluster of Excellence "RESIST", "REBIRTH - Research center for translational and regenerative medicine" as well as the "German Center for Lung Research (DZL)". The lab's main interest is to develop new cell-based treatment approaches for rare and common diseases, affecting primarily the lung but also different other organs. For this purpose, we are using multipotent and pluripotent stem cells. Furthermore, the lab aims to combine translational stem cell research with basic biology in order to gain new insights into human hematopoietic development and related disease pathophysiology of congenital diseases with a strong focus on infectious diseases. This understanding ultimately leads to the investigation of new ways of blood-cell-farming technologies, using scalable hematopoietic differentiation systems to pave the way for cell-based immunotherapies.
