Angewandte Stammzell- und Translationale Makrophagen- Forschung

Applied Stem Cells and Translational Macrophage Research

Forschungsschwerpunkt

Die AG Lachmann ist Mitglied im Cluster of Excellence „RESIST“,  „REBIRTH – Forschungszentrum für Translationale und Regenerative Medizin“ und dem „DZL - Deutschen Zentrum für Lungenforschung“. Die Arbeitsgruppe befasst sich mit der Entwicklung von neuartigen, zell-basierten Therapien für seltene und häufige Erkrankungen mit einem Schwerpunkt für Lungenerkrankungen. Dabei werden unterschiedliche Typen von Stammzellen, wie z.B. induzierte pluripotente Stammzellen (iPSC), genutzt. Die Arbeiten verbinden translationale Stammzellforschung mit neuesten Einblicken in die Entstehung von Krankheiten, hierbei liegt der Fokus auf Infektionskrankheiten. Das resultierende verbesserte Verständnis wird in die Entwicklung von innovativen Technologien zur Gewinnung von Blutzellen (Schwerpunkt Fresszellen) überführt, um daraus zukunftsfähige, zell-basierte Immuntherapien für Patienten zu entwickeln.

Focus of research

The lab is a member of the Cluster of Excellence “RESIST”, “REBIRTH – Research center for translational and regenerative medicine” as well as the “German Center for Lung Research (DZL)”. The lab´s main interest is to develop new cell-based treatment approaches for rare and common diseases, affecting primarily the lung but also different other organs. For this purpose, we are using multipotent and pluripotent stem cells. Furthermore, the lab aims to combine translational stem cell research with basic biology in order to gain new insights into human hematopoietic development and related disease pathophysiology of congenital diseases with a strong focus on infectious diseases. This understanding ultimately leads to the investigation of new ways of blood-cell-farming technologies, using scalable hematopoietic differentiation systems to pave the way for cell-based immunotherapies.

News

Paper in JExpMed

Congratulations to Anna-Lena for her paper published in JExpMed on impaired respiratory burst in PKCd deficient patients

More Info

Cover Story and Review

Congratulations to Miri and Mania for their cover story and review about alveolar macrophages in lung homeostasis and targeted therapies.

More Info

Macrophages at "BioSpektrum"

Read our latest overview about the potential of macrophages and upcoming therapies.

More Info

Zellen der Zukunft

Den Körper mit Zellen heilen zu können – dieses ehrgeizige Ziel verfolgen Wissenschaftlerinnen und Wissenschaftler der Medizinischen Hochschule Hannover (MHH). Professor Dr. Nico Lachmann und Dr.…

More Info

First MD student defending her MD thesis

We are proud to announce that Jenny Lam, our first MD student, successfully defended her MD thesis on macrophages, ipsc and the disease model for IFNGR1 deficiency! It was published previously in…

Dr. Nico Lachmann is now Professor at MHH. Congrats!:)

We are happy to announce, that our group head is now associate professor (W2) at Hannover Medical School investigating new forms of treatment targeting infections of the lower respiratory tract.

Excellence in Research Award

The American Society for Gene and Cell Therapy (ASGCT) awards the work of Kathrin Haake with an “Excellence in Research” award.

 

 

More Info

Prestigious ERC starting grant for the Lachmann Lab

 

 

 

 

More Info

Team and Open Positions
More Info
Publications
More Info
Funding and Collaborations
More Info
News (archive)
More Info
IP/TEC Offer
More Info

Research Focus

Reprogramming and Disease Modelling

More Info

Hematopoietic Differentiation and Cell Therapies

More Info

Macrophage Development and Organoids

More Info

Funding