Doctorates and Master's theses
Doctorates and Master's theses since 1997
Wittköpper, Judith Carmela (Dr. med.). Effects of non-pulsatile ventricular assist devices on the autonomic nervous system. 2021
Hansen, Alice Bernadette (Dr. med. dent.). Effects of weight-loss surgery on obesity-associated diseases and their pharmacotherapy. 2020
Skopp, Alexander (Dr. med.). Regulation of G0S2 expression in human adipose tissue. 2017
Laidig, Friederike (Dr. rer. biol. hum.). Evaluation of a measure to increase drug therapy safety in outpatients. 2016
Jelka Ahrens (Dr. med.). Influence of electrical baroreflex stimulation on insulin resistance in patients with treatment-resistant hypertension. 2016
Friggemann, Nadine (Dr. med.). Role of the cannabinoid receptor type 1 for the energy metabolism of human adipocytes. 2015
Schulke, Claudia Theresia (Dr. rer. nat.). Effects of implementing guided antibacterial therapy (antibiotic stewardship) on the care of patients in a surgical intensive care unit : a retrospective case-control study. 2015
Braun Exner, Lousia (Dr. med.). Influence of obesity and weight reduction on progranulin, PEDF, betatrophin and adipolin. 2015
Kerstin Boldt (Dr. rer. nat.). Development of an approach for the automated detection of a need for clinical-pharmaceutical care from SHI routine data using data mining. University of Bremen 2015.
Hegemann, Katrin (Dr. med.). Sympathetic activity and circulatory reflexes in patients with intracorporeally implanted ventricular assist devices compared to healthy volunteers. 2014
Trettin, Arne Jens (Dr. rer. nat.). Development and establishment of a model for the determination of oxidative-nitrative stress in vivo in humans based on the nitration of orally administered paracetamol. 2014
Henrik Hochbrügge (Dr. rer. biol. hum.). Evaluation of electronic drug expert systems in the application environment of Hannover Medical School. 2013
Anne Nadine Seifert (Dr. med.). The endocannabinoid system in multisomatoform disorder. 2013
Buck, Anna (Dr. med.). The L-arginine-nitric oxide metabolic pathway in preterm infants. 2013
Anke Böhmer (Dr. rer. nat.). Nitrite-dependent NO bioactivity in the circulation: role of hemoglobin, carbonic anhydrases and NO synthase. 2013
Carina Jarzimski (Dr. rer. biol. hum.). The influence of propofol anesthesia on the endocannabinoid system. 2013
Sabine Dehnert (Dr. rer. biol. hum.). In vitro metabolism of the new lipophilic and cell membrane-permeable NO donor S-nitroso-N-acetylsysteine ethyl ester (SNACET) in human blood: Possible consequences for pharmacokinetic studies on SNACET. 2013
Marion Wurr (Dr. med. vet.). Investigations on the importance of inducible cyclooxygenase for atherogenesis in cholesterol-fed rabbits. 2013
Schmidt, Mario (Master's thesis in biochemistry). Development, validation and application of LC-MS/MS methods for the quantitative determination of S-nitrosoglutathione and its metabolites in human plasma. 2012
Julia Reinke (Master thesis Biomedicine). Effect of natriuretic peptides on the energy metabolism of human skeletal muscle cells. 2012
Jan Thomas Michaelsen (Dr. med.). Development, validation and application of an HPLC method for the investigation of nitrite-induced oxidation of glutathione (GSH) and oxyhemoglobin in human erythrocytes. 2012
Alexander A. Zörner (Dr. rer. nat.). Development, validation and application of GC-MS/MS and LC-MS/MS methods for the quantification of the endocannabinoids anandamide and 2-arachidonoylglycerol in blood plasma and bronchoalveolar fluid from clinical studies. 2011
Völkel, Monique Karin (Dr. med.). Conception and implementation of a Computerized Physician Order Entry System with special consideration of risk minimization in drug therapy. 2011
Christin Rakers (Master thesis Biochemistry). Development, evaluation and application of an LC-MS/MS method for the determination of FAAH activity in biological material. 2011
Ivonne Klink (Dr. med.). Physiological effects of growth hormone on parameters of nitric oxide metabolism. 2011
Gesine Picksak (Dr. rer. biol. hum.). Drug safety - A scientific analysis based on prescription data. 2011
Alexandra Schwarz (Dr. med.). Distribution of nitrite in blood compartments and importance of carbonic anhydrase for the transport, metabolism and elimination of nitrite: In vitro and in vivo studies in humans. 2010
V. Vi Pham (Dr. med.). NO metabolic pathway, oxidative and nitrative stress and role of nitrite in chronic inflammatory rheumatism: GC-MS/MS analysis of biomarkers 15(S)-8-iso-PGF2a and 3-nitrotyrosine in urine. 2010
Sabine Rothmann (Dr. rer. biol. hum.). Pilot study on the effect of L-arginine in patients with coronary artery disease after angioplasty and method development for the determination of MDA in plasma as a PFB derivative. 2010
Markus Flentje (Dr. med.). Effects of thiols on the activity of NO synthase and on the bioavailability of NO: evidence for the function of NO synthase as oxyhemoglobin. 2010
Jessica Y. Lachmuth (Dr. rer. biol. hum.). The APAV pilot study: "L-arginine in patients with peripheral arterial occlusive disease". 2008
Brockschnieder Bertram (Dr. rer. biol. hum.). "Prometheus" model of an expert system for individualized drug dosing. 2008
Ruxandra Sabau (Dr. rer. biol. hum.). "Prometheus" model of an expert system for individualized drug dosing. 2008
Kristine Chobanyan (Dr. med.). Development, validation and application of GC/MS methods for the determination of DDAH activity in vitro and in vivo: Evaluation of the role of S-nitrosothiols as potential inhibitors of DDAH activity. 2008
Kristina Denker (Dr. med.). Chemistry and biochemistry of peroxynitrite. Development of analytical methods and their application to elucidate the mechanisms of peroxynitrite formation and metabolism. 2007.
Verena Marhauer (Dr. med.). Effects of the specific COX-2 inhibitor celecoxib on prostanoid synthesis and plasma renin activity in healthy volunteers. 2007.
Meike Rehnelt (Dr. rer. hum. biol.). Studies on the long-term stability of the new nitric oxide (NO) donor S-nitroso-N-acetylcysteine ethyl ester (SNACET) in various pharmaceutical formulations, especially for transdermal application in the therapy of NO-dependent dysfunctions. 2007
Athanassia Warnecke (Dr. med.). Studies on the formation of S-nitrosoalbumin from low molecular weight S-nitrosothiols and albumin in the rat and on the significance of the underlying S-transnitrosylation reaction as a new therapeutic approach for potential S-nitroso-containing pharmaceuticals. 2006
Dirk Martin Georg Fahrenholz (Dr. med.). The influence of sulfasalazine and its metabolites on leukotriene and thromboxane synthesis in monocytes and neutrophil granulocytes. 2006
Jonas Niemann (Dr. med.). Effects of thiols and S-nitrosothiols on the activity of cyclooxygenase-1 and -2: importance of Fe/S/NO interactions for catalytic activity. 2005
Iris Mevius (Dr. med.). Assessment of oxidative stress and the L-arginine/NO metabolic pathway during reperfusion under liver transplantation in humans. 2005
Christina Josefa Mehls (Dr. med.). 3-Nitrotyrosine as a biomarker of oxidative stress in renal insufficiency and under beta-adrenoceptor antagonists in healthy volunteers: Development and application of a gas chromatography-tandem mass spectrometry method for the determination of 3-nitrotyrosine in human plasma. 2004
Christine Thünemann (Dr. med.). The role of nitric oxide (NO) in the relaxation of human arteries by somatotropin and insulin-like growth factor 1. 2004
Jochen U. Schnurrer (Dr. rer. hum. biol.). Development of an expert system for the optimization of pharmacotherapy. 2004
Henrike Lenzen (Dr. med.). The Multicenter CARDIAC Study: Relationship between plasma concentrations of asymmetric dimethylarginine (ADMA) and cardiovascular risk. 2004
Sonja Rojczyk (Dr. med.). Effects of nebivolol on nitric oxide synthesis and oxidative stress in healthy volunteers. 2004
Friederike K. Stutzer (Dr. med.). Effects of isosorbide dinitrate (ISDN) and pentaerythrityl tetranitrate (PETN) on biomarkers of oxidative stress in healthy volunteers. 2003
W. Alexander Osthaus (Dr. med.). Nitric oxide and prostanoid production in rats with adjuvant arthritis - effects of dexamethasone, L-NAME, non-steroidal anti-inflammatory drugs and the radical scavenger U-74389G. 2003
Jochen Muke (Dr. med.). Studies on the effect of L-arginine. 2002
Stefanie A. Fahlbusch (Dr. med.). Effects of carvedilol on the formation of free radicals in cultured human endothelial cells and in healthy volunteers. 2002
Bettina Wagner (Dr. med.). Comparison of the effects of meloxicam and indomethacin on plasma renin activity and prostanoid synthesis in healthy volunteers. 2002
Matthias Löffler (Dr. med.). Investigations into the mechanism of action of the hypotensive effect of the amino acid L-arginine. 2001.
Karsten Sydow (Dr. med.). Interaction between L-arginine-NO metabolism and homocysteine metabolism: Studies on cultured human endothelial cells in patients with PAD. 2001
Henrik-Tobias Arkenau (Dr. med.). Investigation of the role of nitric oxide metabolism for vasodilation in chronic liver diseases and liver cirrhosis. (Supervision together with PD Dr. K.H.W. Böker, Dept. of Gastroenterology and Hepatology, MHH). 2001
Edzard Schwedhelm (Dr. rer. nat.). Isoprostanes and 3-nitrotyrosine as new index parameters of oxidative stress in vivo: analysis, formation, metabolism and biological significance. 2000
Jörg Sandmann (Dr. rer. nat.). Studies on the significance of the S-transnitrosylation reaction for the formation, metabolism and mediation of the biological activities of NO and S-nitroso substances. 2000
Kathrin Susanne Tewes (Dr. rer. hum. biol.). Studies on the suitability of the potential acetylsalicylic acid prodrug guaimesal and of novel S-nitroso compounds for use as platelet aggregation inhibitors and for the treatment of erectile dysfunction. 2000
Heike Alz (Dr. rer. hum. biol.). Development of a computerized expert system for dose calculation and adjustment in high-risk patients. 1999
Ingmar Trapp (Dr. med.). Investigation of the in vivo synthesis of different prostanoids and endothelium-derived relaxing factor in healthy volunteers treated with torasemide - A double-blind cross-over monocenter study. 1999
Robert Alz (Dr. med. vet.). Investigation of the effects of 5-aminosalicylic acid, prednisolone and Subreum® on nitric oxide synthesis and disease activity in rats with adjuvant arthritis. 1997
Conrad Stefan Rossa (Dr. med.). Chemistry, biochemistry and pharmacology of low molecular weight S-nitroso compounds and S-nitroso-albumin: Development of analytical methods and their application to elucidate the mechanisms of formation, metabolism and biological action of S-nitroso compounds. 1997Skopp, Alexander (Dr. med.). Regulation of G0S2 expression in human adipose tissue. 2017
Laidig, Friederike (Dr. rer. biol. hum.). Evaluation of a measure to increase drug therapy safety in outpatients. 2016
Jelka Ahrens (Dr. med.). Influence of electrical baroreflex stimulation on insulin resistance in patients with treatment-resistant hypertension. 2016
Friggemann, Nadine (Dr. med.). Role of the cannabinoid receptor type 1 for the energy metabolism of human adipocytes. 2015
Schulke, Claudia Theresia (Dr. rer. nat.). Effects of implementing guided antibacterial therapy (antibiotic stewardship) on the care of patients in a surgical intensive care unit : a retrospective case-control study. 2015
Braun Exner, Lousia (Dr. med.). Influence of obesity and weight reduction on progranulin, PEDF, betatrophin and adipolin. 2015
Kerstin Boldt (Dr. rer. nat.). Development of an approach for the automated detection of a need for clinical-pharmaceutical care from SHI routine data using data mining. University of Bremen 2015.
Hegemann, Katrin (Dr. med.). Sympathetic activity and circulatory reflexes in patients with intracorporeally implanted ventricular assist devices compared to healthy volunteers. 2014
Trettin, Arne Jens (Dr. rer. nat.). Development and establishment of a model for the determination of oxidative-nitrative stress in vivo in humans based on the nitration of orally administered paracetamol. 2014
Henrik Hochbrügge (Dr. rer. biol. hum.). Evaluation of electronic drug expert systems in the application environment of Hannover Medical School. 2013
Anne Nadine Seifert (Dr. med.). The endocannabinoid system in multisomatoform disorder. 2013
Buck, Anna (Dr. med.). The L-arginine-nitric oxide metabolic pathway in preterm infants. 2013
Anke Böhmer (Dr. rer. nat.). Nitrite-dependent NO bioactivity in the circulation: role of hemoglobin, carbonic anhydrases and NO synthase. 2013
Carina Jarzimski (Dr. rer. biol. hum.). The influence of propofol anesthesia on the endocannabinoid system. 2013
Sabine Dehnert (Dr. rer. biol. hum.). In vitro metabolism of the new lipophilic and cell membrane-permeable NO donor S-nitroso-N-acetylsysteine ethyl ester (SNACET) in human blood: Possible consequences for pharmacokinetic studies on SNACET. 2013
Marion Wurr (Dr. med. vet.). Investigations on the importance of inducible cyclooxygenase for atherogenesis in cholesterol-fed rabbits. 2013
Schmidt, Mario (Master's thesis in biochemistry). Development, validation and application of LC-MS/MS methods for the quantitative determination of S-nitrosoglutathione and its metabolites in human plasma. 2012
Julia Reinke (Master thesis Biomedicine). Effect of natriuretic peptides on the energy metabolism of human skeletal muscle cells. 2012
Jan Thomas Michaelsen (Dr. med.). Development, validation and application of an HPLC method for the investigation of nitrite-induced oxidation of glutathione (GSH) and oxyhemoglobin in human erythrocytes. 2012
Alexander A. Zörner (Dr. rer. nat.). Development, validation and application of GC-MS/MS and LC-MS/MS methods for the quantification of the endocannabinoids anandamide and 2-arachidonoylglycerol in blood plasma and bronchoalveolar fluid from clinical studies. 2011
Völkel, Monique Karin (Dr. med.). Conception and implementation of a Computerized Physician Order Entry System with special consideration of risk minimization in drug therapy. 2011
Christin Rakers (Master thesis Biochemistry). Development, evaluation and application of an LC-MS/MS method for the determination of FAAH activity in biological material. 2011
Ivonne Klink (Dr. med.). Physiological effects of growth hormone on parameters of nitric oxide metabolism. 2011
Gesine Picksak (Dr. rer. biol. hum.). Drug safety - A scientific analysis based on prescription data. 2011
Alexandra Schwarz (Dr. med.). Distribution of nitrite in blood compartments and importance of carbonic anhydrase for the transport, metabolism and elimination of nitrite: In vitro and in vivo studies in humans. 2010
V. Vi Pham (Dr. med.). NO metabolic pathway, oxidative and nitrative stress and role of nitrite in chronic inflammatory rheumatism: GC-MS/MS analysis of biomarkers 15(S)-8-iso-PGF2a and 3-nitrotyrosine in urine. 2010
Sabine Rothmann (Dr. rer. biol. hum.). Pilot study on the effect of L-arginine in patients with coronary artery disease after angioplasty and method development for the determination of MDA in plasma as a PFB derivative. 2010
Markus Flentje (Dr. med.). Effects of thiols on NO synthase activity and NO bioavailability: evidence for the function of NO synthase as oxyhemoglobin. 2010
Jessica Y. Lachmuth (Dr. rer. biol. hum.). The APAV pilot study: "L-arginine in patients with peripheral arterial occlusive disease". 2008
Brockschnieder Bertram (Dr. rer. biol. hum.). "Prometheus" model of an expert system for individualized drug dosing. 2008
Ruxandra Sabau (Dr. rer. biol. hum.). "Prometheus" model of an expert system for individualized drug dosing. 2008
Kristine Chobanyan (Dr. med.). Development, validation and application of GC/MS methods for the determination of DDAH activity in vitro and in vivo: Evaluation of the role of S-nitrosothiols as potential inhibitors of DDAH activity. 2008
Kristina Denker (Dr. med.). Chemistry and biochemistry of peroxynitrite. Development of analytical methods and their application to elucidate the mechanisms of peroxynitrite formation and metabolism. 2007.
Verena Marhauer (Dr. med.). Effects of the specific COX-2 inhibitor celecoxib on prostanoid synthesis and plasma renin activity in healthy volunteers. 2007.
Meike Rehnelt (Dr. rer. hum. biol.). Studies on the long-term stability of the new nitric oxide (NO) donor S-nitroso-N-acetylcysteine ethyl ester (SNACET) in various pharmaceutical formulations, especially for transdermal application in the therapy of NO-dependent dysfunctions. 2007
Athanassia Warnecke (Dr. med.). Studies on the formation of S-nitrosoalbumin from low molecular weight S-nitrosothiols and albumin in the rat and on the significance of the underlying S-transnitrosylation reaction as a new therapeutic approach for potential S-nitroso-containing pharmaceuticals. 2006
Dirk Martin Georg Fahrenholz (Dr. med.). The influence of sulfasalazine and its metabolites on leukotriene and thromboxane synthesis in monocytes and neutrophil granulocytes. 2006
Jonas Niemann (Dr. med.). Effects of thiols and S-nitrosothiols on the activity of cyclooxygenase-1 and -2: importance of Fe/S/NO interactions for catalytic activity. 2005
Iris Mevius (Dr. med.). Assessment of oxidative stress and the L-arginine/NO metabolic pathway during reperfusion under liver transplantation in humans. 2005
Christina Josefa Mehls (Dr. med.). 3-Nitrotyrosine as a biomarker of oxidative stress in renal insufficiency and under beta-adrenoceptor antagonists in healthy volunteers: Development and application of a gas chromatography-tandem mass spectrometry method for the determination of 3-nitrotyrosine in human plasma. 2004
Christine Thünemann (Dr. med.). The role of nitric oxide (NO) in the relaxation of human arteries by somatotropin and insulin-like growth factor 1. 2004
Jochen U. Schnurrer (Dr. rer. hum. biol.). Development of an expert system for the optimization of pharmacotherapy. 2004
Henrike Lenzen (Dr. med.). The Multicenter CARDIAC Study: Relationship between plasma concentrations of asymmetric dimethylarginine (ADMA) and cardiovascular risk. 2004
Sonja Rojczyk (Dr. med.). Effects of nebivolol on nitric oxide synthesis and oxidative stress in healthy volunteers. 2004
Friederike K. Stutzer (Dr. med.). Effects of isosorbide dinitrate (ISDN) and pentaerythrityl tetranitrate (PETN) on biomarkers of oxidative stress in healthy volunteers. 2003
W. Alexander Osthaus (Dr. med.). Nitric oxide and prostanoid production in rats with adjuvant arthritis - effects of dexamethasone, L-NAME, non-steroidal anti-inflammatory drugs and the radical scavenger U-74389G. 2003
Jochen Muke (Dr. med.). Studies on the effect of L-arginine. 2002
Stefanie A. Fahlbusch (Dr. med.). Effects of carvedilol on the formation of free radicals in cultured human endothelial cells and in healthy volunteers. 2002
Bettina Wagner (Dr. med.). Comparison of the effects of meloxicam and indomethacin on plasma renin activity and prostanoid synthesis in healthy volunteers. 2002
Matthias Löffler (Dr. med.). Investigations into the mechanism of action of the hypotensive effect of the amino acid L-arginine. 2001.
Karsten Sydow (Dr. med.). Interaction between L-arginine-NO metabolism and homocysteine metabolism: Studies on cultured human endothelial cells in patients with PAD. 2001
Henrik-Tobias Arkenau (Dr. med.). Investigation of the role of nitric oxide metabolism for vasodilation in chronic liver diseases and liver cirrhosis. (Supervision together with PD Dr. K.H.W. Böker, Dept. of Gastroenterology and Hepatology, MHH). 2001
Edzard Schwedhelm (Dr. rer. nat.). Isoprostanes and 3-nitrotyrosine as new index parameters of oxidative stress in vivo: analysis, formation, metabolism and biological significance. 2000
Jörg Sandmann (Dr. rer. nat.). Studies on the significance of the S-transnitrosylation reaction for the formation, metabolism and mediation of the biological activities of NO and S-nitroso substances. 2000
Kathrin Susanne Tewes (Dr. rer. hum. biol.). Studies on the suitability of the potential acetylsalicylic acid prodrug guaimesal and of novel S-nitroso compounds for use as platelet aggregation inhibitors and for the treatment of erectile dysfunction. 2000
Heike Alz (Dr. rer. hum. biol.). Development of a computerized expert system for dose calculation and adjustment in high-risk patients. 1999
Ingmar Trapp (Dr. med.). Investigation of the in vivo synthesis of different prostanoids and endothelium-derived relaxing factor in healthy volunteers treated with torasemide - A double-blind cross-over monocenter study. 1999
Robert Alz (Dr. med. vet.). Investigation of the effects of 5-aminosalicylic acid, prednisolone and Subreum® on nitric oxide synthesis and disease activity in rats with adjuvant arthritis. 1997
Conrad Stefan Rossa (Dr. med.). Chemistry, biochemistry and pharmacology of low molecular weight S-nitroso compounds and S-nitroso albumin: Development of analytical methods and their application to elucidate the mechanisms of formation, metabolism and biological action of S-nitroso compounds. 1997