Single center: Congenital kidney diseases
Patients of all ages (i.e. from newborns to adults) with congenital and hereditary ("inherited") kidney diseases are treated.
The incidences of congenital and hereditary kidney diseases are between 1:5000 (urethral valves) and 1:50000 (focal segmental glomerulosclerosis); this means that they belong to the group of rare diseases (prevalence < 5:10,000). The cross-regional networking of scientists involved in the disease contributes to optimal clinical care and the acquisition of groundbreaking scientific findings.
Congenital kidney diseases pose a major diagnostic challenge, as a definitive diagnosis can often only be made by combining complex biochemical findings, imaging and renal biopsy and/or genetic findings. In addition to the urogenital tract, other organ systems such as the central nervous system, eyes, ears, skeletal system, gastrointestinal tract and cardiovascular system are often affected, so that comprehensive interdisciplinary diagnostics are required at the time of diagnosis.
Causal therapy is often not possible, so that in many patients the development of terminal renal failure and the need for dialysis or kidney transplantation is to be expected in the long term. In principle, we strive for the earliest possible or pre-emptive kidney transplantation, if necessary via a living donation from a close relative of the patient. This concept has been successfully implemented at the MHH for a long time.
Competencies of the individual center:
Specialized expertise in the care of patients with...
- Cystic kidneys e.g. autosomal recessive polycystic kidney disease (ARPKD), nephronophthisis
- congenital malformations of the kidneys and urogenital tract (CAKUT)
- glomerular kidney diseases e.g. atypical hemolytic uremic syndrome
- Alport syndrome
- focal segmental glomerulosclerosis
- tubular kidney diseases e.g. hypophosphatemic rickets, Bartter syndrome
- steroid-resistant nephrotic syndrome
- Nephritic syndrome
