Electrode technology
Neuroelectrodes, which enable permanent, medically safe and spatially high-resolution electrophysiological measurement and stimulation in the central nervous system, are used as neuroelectrical interfaces, e.g. for deep brain stimulation or as central auditory prostheses.
As part of a DFG-funded cooperation with the Barcikowski working group, Technical Chemistry I at the University of Duisburg Essen, we were able to show that coating electrodes with platinum nanoparticles optimizes the resistance of recording and stimulation electrodes without affecting the biocompatibility of the electrodes. We have also investigated whether the quality of electrophysiological conduction is improved by such a coating.
As part of an EU-funded research project led by Prof. Doll (Fraunhofer Institute for Toxicology and Experimental Medicine ITEM Translational Biomedical Engineering), novel electrode arrays were implanted that can be used to chronically record neuronal activity in a similar way to EEG but with higher resolution. Such electrode arrays can later be used to record neuronal activity as part of adaptive DBS in patients.
Ramesh V, Stratmann N, Schaufler V, Angelov SD, Nordhorn ID, Heissler HE, Martínez-Hincapié R, Čolić V, Rehbock C, Schwabe K, Karst U, Krauss JK, Barcikowski S. Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition. Adv Healthc Mater. 2022 Dec;11(23):e2102637.
Ramesh V, Rehbock C, Giera B, Karnes JJ, Forien JB, Angelov SD, Schwabe K, Krauss JK, Barcikowski S. Comparing Direct and Pulsed-Direct Current Electrophoretic Deposition on Neural Electrodes: Deposition Mechanism and Functional Influence. Langmuir. 2021 Aug 6.
Koenen S, Rehbock C, Heissler HE, Angelov SD, Schwabe K, Krauss JK, Barcikowski S. Optimizing in Vitro Impedance and Physico-Chemical Properties of Neural Electrodes by Electrophoretic Deposition of Pt Nanoparticles. Chemphyschem. 2017 May 5;18(9):1108-1117.
Angelov SD, Koenen S, Jakobi J, Heissler HE, Alam M, Schwabe K, Barcikowski S, Krauss JK. Electrophoretic deposition of ligand-free platinum nanoparticles on neural electrodes affects their impedance in vitro and in vivo with no negative effect on reactive gliosis. J Nanobiotechnology. 2016 Jan 12;14:3.
Collaborations
Prof. Dr. Theodor Doll (Clinical Department of Ear, Nose and Throat Medicine, MHH)
Prof. Dr. Stephan Barcikowski, Dr. Christoph Rehbock (Institute for Technical Chemistry, University of Duisburg-Essen)
Sponsorship
MDOT-Proposal-SEP-210512779
DFG - KR 2931/3-3