first cloned 13 genetically very different HCV variants. These viruses belong to five of the eight most widespread HCV genotypes and therefore cover a very broad spectrum of the genetic diversity of the [...] These NBTs cannot be predicted from genetic sequence comparisons, but represent different functional properties of the viral envelope proteins with respect to human antibodies (Bankwitz et al. Gut 2021) [...] mechanisms of protection and for prioritization of vaccines. Here, we used a unique collection of human specimens and HCV strains to develop HCV reference viruses for quantification of neutralizing antibodies
2019 High-throughput methods and stem cell technology support the search for CFTR modulators The genetic lung disease cystic fibrosis cannot yet be cured. Since November 2015, the first therapy with CFTR [...] disease-specific induced pluripotent stem cells (iPSCs) in a high-throughput process. Until now, the genetic lung disease cystic fibrosis has been considered incurable; for a long time, only symptomatic treatment [...] is based on the use of induced pluripotent stem cells (iPSCs), which are obtained by reprogramming human somatic cells. These cells can be multiplied almost indefinitely in the laboratory and then differentiated
Degrees Doctoral Degree Institute of Biomedical Ethics and History of Medicine, Faculty of Medicine, University of Zürich, Switzerland, May 2015 Dissertation Title: “Organ Selling, Human Dignity and its Violation: [...] for the Humanities and Social Sciences). Associate researcher at the Department of Philosophy, University of Calgary, AB, Canada, November 2015 until December 2017. Research assistant in “Human Dignity [...] Caregivers’ Perspective on Biomarkers with Laypersons’ Attitudes towards Genetic Testing of Dementia Prediction”. New Genetics and Society . 39(1): 52-79. doi: 10.1080/14636778.2019.1637719 Alpinar-Sencan
research projects: Molecular biology of breast cancer Molecular genetics of ovarian cancer Molecular genetics of endometrial cancer Genetic epidemiology of cervical cancer Radiation sensitivity and DNA repair [...] biology or life sciences Intramural collaborations: Clinics of Radiation Oncology Institute of Legal Medicine Institute of Experimental Hematology Funding: Bruno and Helene Jöster Foundation Claudia von
Associate at the Institute of Neuroanatomy and Cell Biology, Hannover Medical School 2000–2002 Ph.D. at the Clinical Department of Neurosurgery, Hannover Medical School, and the Institute of Pharmacology [...] Düsseldorf (Intermediate Examination) Academic Career 2011 – present: Research Group Leader at the Institute of Neuroanatomy and Cell Biology, Hannover Medical School July 2005–October 2005: Visiting Scientist [...] Pharmacy, and Toxicology at the University of Veterinary Medicine Hannover. Research Associate at the Institute of Anatomy II, University Hospital of Heinrich Heine University Düsseldorf Additional Qualifications
Principal investigator PD Dr. Jens Bohne Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone +49 511 532 4307 Departmental Secretary [...] l RNA expression. On the cellular side we are interested in non-coding mutations causing various human diseases. Both areas follow our central idea: A deeper knowledge of both viral gene expression and [...] rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B. PLoS Genet. 2020 Apr 8;16(4):e1008690. 3. Krooss SA, Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q
strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining [...] alleles with low stimulatory potential for the potential transplant recipient. Together with further "genetic engineering" in the context of ex vivo perfusion, it is thus possible to select or generate a xenograft
Jonathan Lühmann GERMANY Luehmann.Jonathan @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Optical Mapping to detect structural genomic variants in cancer Jonathan was class [...] Thum / Dr. Christian Bär (IMTTS) Project: Screening and validation of natural compound libraries in human iPSC-cardiomyocytes for the treatment of Fabry disease Final exam June 2024 Bushra Khan INDIA khan [...] Sommer @ item.fraunhofer.de Supervisors: Prof. Dr. Armin Braun / Dr. Katherina Sewald (Fraunhofer Institute ITEM) Project: Immune-related mechanisms of IL-2-induced skin rash and lung toxicity Final exam
is to vascularize organoids and to produce functional kidney tissue from human stem cells. We use zebrafish embryos with genetic markers for renal cells, macrophages and endothelium and LSM microscopy to [...] mechanisms of vasculogenesis. In parallel, we are studying new vessel formation in human renal organoids. We have discovered that human macrophages strongly influence vascularization and endothelial differentiation [...] hypothesis is that impaired signal transduction of VEGF is responsible for aging and that targeted genetic manipulation can arrest these aging and dedifferentiation processes. Our second research project
Interventional Radiology Institute of Human Genetics Institute for Radiotherapy and Special Oncology Comprehensive Cancer Center (CCC) Hannover Center for Clinical Trials Clinic for Pediatric Pneumology, A [...] insights into the causes and course of diseases. Cooperating institutes and departments at the MHH Institutes and departments Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover [...] collection and cross-institutional exchange of medical data for health care and research. Research Research also benefits directly from the possibilities of exchanging data across institutions. On the one hand