vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier [...] Cancer Res. 2016;209:17-35. doi: 10.1007/978-3-319-42934-2_2. Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform. Hübner [...] Jordans S, Dilloo D. J Cell Mol Med 2022;26(23):5832-5845 DOI: 10.1111/jcmm.17604 Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli

ChIPSeq-analyses mRNA biology Single-nuclei sequencing Crispr/Cas genetic engineering Collaborating Partners: Prof. Dr. Lars Dölken (Institute of Virology, MHH) For collaboration requests, please contact Dr

hospitals in Germany, so it is especially valuable for research with human samples/human models. My current project works with human samples, so it is very important for me to have this research environment [...] Impact of immunmodulatory treatment of ARDS of different origin Supervisor: Dr. Theresa Graalmann, Institute for Experimental Infection Research, AG Translationale Immunology, Twincore As a Ph.D. student in [...] ity of prenatal-derived γδ T cells in neonatal infections Supervisor: Prof. Dr. Sarina Ravens, Institute of Immunology, MHH The PhD Program „Infection Biology“ & “DEWIN” (ZIB) at Hannover Medical School

hypertrophy in hPSC-derived cardiomyocytes based on pharmacological stimuli or genetic mutations e.g. in the MYH7 or MYBPC3 genetic loci (DFG project cMyBP-C-Mutationen FKZ: ZW 64/4-2). This research strongly [...] AG Zweigerdt Zweigerdt Lab Applying human pluripotent stem cells (hPSCs) , we are working on aspects of developmental biology and regenerative medicine focused on the heart as well other tissues and lineages [...] HFOs), and studying cardiac hypertrophy in hPSC-cardiomyocytes based on pharmacological stimuli or genetic mutations (e.g. in MYH7 or MYBPC3). Collaboration with Industry : Besides academic partners (within

from the Institute for Laboratory Animals with histopathologic skills from organ experts in human pathology. In order to enable optimal patho-anatomical interpretation of animal models for human disease [...] behind xPa is to involve pathology specialists who have profound experience and skills in particular human organs, e.g. lung or kidney, in the analysis of the corresponding organ in animals also, in order [...] with novel and experimental therapies and thus acquire the necessary knowledge for interpreting human tissue specimens derived from patients treated by experimental therapy modalities. Consequently, xPa

Lehre Lehre im Institut für Biophysikalische Chemie Das Institut bietet zahlreiche Lehrveranstaltungen in Bachelor und Master Biochemie, den Studiengängen Human- und Zahnmedizin sowie den Studiengang Biologie

conference in Glasgow © Anna Beening June 21, 2023 "From June 10 to 13, 2023, the 56th European Human Genetics Conference took place in Glasgow. This annual conference brings together geneticists from all [...] and workshops. As part of the StrucMed program of the HBRS, I am currently also researching a human genetics issue for my medical doctoral thesis. Therefore, with the financial support of the Gesellschaft [...] Model. The Hannover Medical School 1961-1971". The guided tour with Professor Heiko Stoff from the Institute of History, Ethics and Philosophy of Medicine at the MHH began in 1961, when the Ministry of Lower

staff/doctoral students: M. Sc. Psych. Josefine Fischer-Jacobs Cooperation: Institute of Human Genetics, Hannover Medical School. Institute of Diagnostic and Interventional Radiology, Hannover Medical School. [...] with genetic and family-related distress. This study provides the first indications in German-speaking countries of the psychological and medical support needs of women with an increased genetic risk and [...] 12/2023. Study description: In view of the growing number of cancer patients and limited financial and human resources, the needs-based planning of psycho-oncological care is becoming increasingly important

effects induced by the human autoallergen α-NAC. J Invest Dermatol. 2014 Jan; 134(6):1570-8 Hradetzky S , Balaji H, Rösner L, Heratizadeh A, Mittermann I, Valenta R, Werfel T: The human skin-associated au [...] Chin WWL, Wieschowski S , Prokein J, Illig T, Strech D (2016) Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes. PLoS Biol 14(8):e1002521. Lennart M. Roesner [...] Heratizadeh A, Crameri R, Garbani M, Scheynius A, Werfel T: Differential cytokine induction by the human skin-associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy

primarily in the respiratory and gastrointestinal tracts. The clinical research group focuses on the genetics and infectiology of CF, the microbiome in the CF airways, microevolution of Pseudomonas aeruginosa [...] for treatment of the basic defect and chronic infections. The group was founded in 1983 at the Institute of Biophysical Chemistry of MHH and transferred to the clinical research group "Molecular pathology [...] research group was initially based in the Center of Biochemistry of the MHH and the later Max Planck Institute for Experimental Endocrinology (now TwinCore) and moved into the new Pediatric Research Center