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myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish and hESC-/hiPSC-CMs). In vitro -differentiated [...] cellular disease models in vitro . hPSC-CMs exhibit a series of immature features compared to ventricular CMs of an adult human heart. Therefore, characterization of hPSC-CMs at different hierarchically [...] factors that could improve the functional maturation of hPSC-CMs in vitro toward a more ventricular-like phenotype; defining the maturation stage of hPSC-CMs at different hierarchically interrelated levels