-free survival (PFS) at 12.5 months compared to 6.3 months (hazard ratio 0.45, 95% CI: 0.38 - 0.54; p<0.00001) and in overall survival (OS) at 31.5 months compared to 16.1 months (hazard ratio 0.47, 95% [...] with the new combination compared to standard therapy. The overall response rate was 68% (95% CI: 63.1-72.1, p<0.00001) and was thus significantly higher than in the comparative arm with chemotherapy, where [...] are currently insufficient for a conclusive assessment. A critical point to note is the comparatively weak comparator arm, which consisted of a change of NHT and thus represents a notoriously weak option

MHH Qualification objective Students complete an internship at an Institute of a university or comparable institution on their own initiative. As a rule, an individually supervised research project is [...] foundations and their self-organization, as well as their ability to work in a team. They are able to compare different methods for solving a problem and select the appropriate one. Students are able to evaluate

German Study Group (WSG) is dedicated to the treatment of HER2-positive early breast cancer. It compares neoadjuvant treatment with trastuzumab-deruxtecan (T-DXd) for 12 or 18 weeks in two experimental [...] Group (WSG) implements an adjuvant dynamic marker-adapted personalized therapy strategy (ADAPT) and compares endocrine therapy plus ribociclib (CDK4/6 inhibitor) with endocrine therapy plus chemotherapy for [...] investigated in more detail. In particular, OGC cells in the tumor stroma of breast carcinomas are compared with multinucleated giant cells that form in the context of inflammatory processes (e.g. in tuberculosis

are indications that the effect of ABX-1431 is comparable to cannabis-based drugs. However, ABX-1431 appears to be more effective and better tolerated compared to cannabis-based drugs. Based on clinical

parallel, two-arm superiority study to investigate the bioavailability and handling of Envarsus® compared to Advagraf® in de novo liver transplant recipients (EnGraft) . Recruitment almost completed TaCDrop [...] assess bioavailability and practicability of two once-daily tacrolimus formulations, Envarsus ® compared with Advagraf, administered in kidney recipients. - Study start planned HOPE perfusion study - in [...] Charité Berlin End-ischaemic hypothermic oxygenated (HOPE) versus normothermic machine perfusion (NMP) compared to conventional cold storage in donation after brain daith (DBD) liver transplantation; a prospective

relatively high single dose to be delivered to a small area and thus destroy it in a targeted manner, comparable to the result of an operation. Source: ENT Clinical Department of the MHH Figure 2 shows an example [...] be arranged with corresponding cooperation partners on request). In principle, all methods offer comparable tumor control rates. Which method is used is always decided individually in consultation with the

Severity Toolbox developed by us provides tools (R packages) that enable researchers to measure, compare and evaluate stress in animals in different ways. In particular, the Relative Severity Assessment [...] be mentioned here, which fuses multidimensional input signals and can be used to quantitatively compare individual animals and groups as well as animal models. Integrated monitoring of clinical vital signs [...] Lena Boldt, Peter Gass, André Bleich, Steven Roger Talbot , Heidrun Potschka. Evidence-based comparative severity assessment in young and adult mice. PLOS ONE 18(10): e0285429 (2023). Maria Reiber, Lara

healthy children can be used as a comparative value for other studies in the future. "So far, only the findings of children with different diseases could be compared," explains the scientist. The study [...] aged three weeks to six years for the first time, tested them for the microorganisms present and compared them with those from cystic fibrosis sufferers of the same age," explains the research group leader

of an osseointegrated prosthetic fitting compared to conventional fittings on gait pattern and joint loading. Two working hypotheses are to be tested: 1a) Compared to healthy subjects, the patients with [...] are either only cosmetic replicas of the lost limb or they only offer greatly simplified functions compared to the human hand. In order to change this, the research project "Softpro - Synergy-based Open-source [...] performed to determine the knee contact forces under the influence of the acting leg muscles and to compare these with the results from the gait analysis. Participants: 142 children with idiopathic varus or

rate in children after kidney transplantation has fallen in recent decades, it is still very high compared to the general population due to early cardiovascular complications. "Our new findings can explain [...] that girls with advanced chronic kidney disease are more prone to developing vascular stiffness compared to boys; this difference persists after transplant." Vascular stiffness is a medical characteristic