addition, there are a number of local and general (systemic) risk factors, such as smoking or poorly controlled blood sugar (diabetes mellitus), which can promote the development and progression of the disease [...] For example, regenerative periodontal surgery is not very successful in heavy smokers and poorly controlled diabetics. The long-term goal is to restore an inflammation-free periodontium and prevent further
killer cells (NK cells) play the biggest role? What mechanisms do the various immune cells use to control the infection? How efficiently does a single immune cell protect the host organism? To answer these [...] Y, Heller K, Ritter C, Keyser KA, Wagner K, Liu X, Messerle M, Stahl FR*, Halle S*, Förster R*. Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of i
doi: 10.1056/NEJMc2036236. PMID: 33882214 MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate. Gutierrez-Prat N, Cubillos-Rojas M, Cánovas B, Kuzmanic A, Gupta J, Igea [...] MB, Gaestel M. Trends Biochem Sci. 43, 158-167. PDF 2017 p38 MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection Menon MB*, Gropengießer J*, Fischer J, Novikova
prior sensitization to efficiently kill virus-infected and tumor cells enabling them to immediately control until lymphocytes of the adopted immune system overtake and terminate infection and tumorigenesis [...] cells can produce several cytokines such as IFN-γ, TNF-α, GM-CSF and IP10 allowing them to also control and regulate immune functions by soluble factors. Other areas of research: innate immunity, immu
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focus Orexin and hippocampus in cognition and metabolism Metabolic stress in the brain and central control of energy metabolism Investigation of neuronal circuits in vivo and in organotypic co-cultures to [...] Nature Communications 2021; 12: 5249. DOI: 10.1038/s41467-021-25380-2 Research highlight: Glucose control. Lewis, S. Nat Rev Neurosci 22, 655 (2021). Doi: 10.1038/s41583-021-00530-z Shp-1 dephosphorylates
(2020) An Erg-driven transcriptional program controls B cell lymphopoiesis. Nature Communications 11(11): 3013. Behrens K and Alexander WS. (2018) Cytokine control of megakaryopoiesis. Growth Factors 36(3 [...] Kueh AJ, Herold MJ, Hilton DJ, Babon JJ, Nicola NA, Behrens K* , Alexander WS*. (2025) Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice. Blood 145(10):
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for providing polarity, tension, stability and adhesive properties to cells in a spatiotemporally controlled manner. We follow an interdisciplinary approach that is based on a methodological framework combining