Ivonne Wieland - Curriculum Vitae Copyright: Christian Wyrwa / wyrwa fotografie Ivonne Wieland studied Human medicine at the Carl Gustav Carus University Hospital at TU Dresden. She completed her studies in [...] inhibitors against coagulation factor VIII in the murine model as well as the characterization of genetic polymorphisms of genes associated with the immune response. She also studies acquired coagulation

and thus trigger leukaemia. Now, an international research team led by Dr. Michael Rothe from the Institute of Experimental Haematology at the Hannover Medical School (MHH) has developed a safety test that [...] studies, however, individual patients developed leukaemia after they had been transplanted with the genetically modified blood stem cells. "This happens when the vector inserts itself near cancer genes and activates [...] conclusive," the scientist emphasises. The IVIM (In Vitro Immortalisation) test developed at the Institute of Professor Dr Axel Schambach several years ago and approved in the USA, Canada, Australia and

Hochschule Hannover, the Fraunhofer Institute for Toxicology and Experimental Medicine, the Institute of Farm Animal Genetics of the Friedrich-Loeffler-Institute (FLI) Mariensee, the Helmholtz Centre [...] Centre for Infection Research Braunschweig and the Max Planck Institute for Molecular Biomedicine Münster. The consortium addresses some of the big questions in health research as well as the associated challenges [...] Structure of Organisation & Governance Coordinators Coordinator: Prof. Dr. Dr. Thomas Thum The Institute of Molecular and Translational Therapeutic Strategies (IMTTS) E-Mail: Thum.Thomas(at)mh-hannover

Courses of the Institute of Cell Biochemistry Teaching for biochemistry students Information on the Biochemistry study programmes Lectures, internships, seminars of the Institute of Cell Biochemistry Teaching [...] the Institute of Cell Biochemistry Teaching for students of Biology / Chemistry / Life Science and the interdisciplinary Bachelor's degree program Lectures, internships, seminars of the Institute of Cell [...] Cell Biochemistry Teaching for students of human medicine and dentistry The documents for teaching students of human medicine and dentistry can be found on the pages of the teaching platform ILIAS.

Single center: Rare diseases of the auditory organs Hearing loss is the most common sensory deficit in humans. Children in particular are also affected to a high degree. Even though newborn hearing screening [...] sensorineural hearing loss can occur with other diseases - this then affects all generations. With genetic diagnostics, we have an increasingly important tool at our disposal to develop new therapeutic procedures

are also life threatening, e.g. Cystic Fibrosis (CF) and surfactant deficiencies (SD). CF is a genetic disease, resulting in a dysfunction of the „Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)“ [...] respiratory system. Cell replacement therapies could be used to regenerate normal lung function in both genetic and acquired pulmonary diseases. Pluripotent stem cells represent a suitable cell source due to their [...] huge impact for both the optimization of differentiation protocols as well as for drug-screening are human iPS reporter cell lines which are generated using TALEN-based homologues recombination ( RG Martin

Hildegard Büning and Professor Dr Axel Schambach agree on this. The gene therapy experts from the Institute of Experimental Haematology at Hannover Medical School (MHH), together with five other experts, [...] in 2020. "On 16 November, less than a fortnight ago, the world's first gene therapy based on this genetic technology was approved in the UK," reports Professor Büning. People suffering from the blood disorders [...] the genes" is already capable of today. "And it will be able to do even more: One idea is to use genetic scissors or 'erasers' in the genome to detect and correct possible malfunctions in common diseases

cells of the haematopoietic system multiply uncontrollably. This form of blood cancer is caused by genetic changes in the bone marrow that occur in the course of life. Therefore, it is mainly older people [...] Medicine, one of the world's most respected medical journals. Surprisingly strong effect also in humans The drugs in question are Ivosidenib and Azacitidine, which have so far been used individually against [...] Professor Heuser. In the clinical trial, the researchers were now also able to demonstrate this effect in humans who had newly diagnosed AML with gene alterations in the IDH1 enzyme. "We were surprised that the

about the molecular biological causes. A research team led by Professor Dr. Christian Bär from the Institute of Molecular and Translational Therapy Strategies of the Hannover Medical School (MHH) now wants [...] and over again. The reason for this is the so-called telomeres, the ends of the chromosomes. The genetic information is stored on the chromosomes. With each cell division, the telomeres shorten a bit. After [...] first investigate the role of immune and organ aging in the heart and lungs. For this purpose, two genetically different, so-called chimeric mouse models are produced, in which the biological ages of organs

2014 – January 2020: PostDoc at the Institute for Clinical Biochemistry (formerly Institute for Cellular Chemistry), MHH June 2010 – July 2014: PhD at the Institute for Clinical Biochemistry Doktorarbeit [...] on the (Glyco-) Proteome of Human Pluripotent Stem Cells“ 2010: diploma thesis at the Diplomarbeit Institute for Clinical Biochemistry, MHH in cooperation with the Institute of Microbiology, University [...] g-Str.1 building J03, floor 03, room 1330 Curriculum Vitae Since December 2021: PostDoc at the Institute for Molecular and Cell Physiology, Hannover Medical School (MHH), Hannover, Germany February 2020