explains Professor Dr. Constanca Figueiredo, senior scientist at the Institute and deputy project leader. In addition, the scientist genetically modified the iPSC and also switched off the HLA characteristics [...] consumption of blood products. A research team led by Professor Dr Rainer Blasczyk, head of the Institute for Transfusion Medicine and Transplant Engineering at the Medical School (MHH), wants to solve [...] groups that have to be taken into account in a transfusion. Tissue characteristics, the so-called human leukocyte antigens (HLA), also play a role. These molecules on the surface of body cells are comparable

of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology and the Institutes of Pathology and Human Genetics want to demonstrate the added value of different liquid biopsies from bile in patients [...] they are confronted with numerous defense and control mechanisms, many of which are genetically controlled. If these genetic guardians are damaged or not sufficiently efficient, the cells continue to grow [...] provide long-term care for cancer patients. This problem is being addressed by a project of the Institute of Sports Medicine under the direction of Prof. Dr. Uwe Tegtbur. The aim is to implement supplementary

Human Genetics (BD P 03) Qualification goals The module provides basic knowledge of human genetics and state-of-the-art diagnostic and bioinformatic analysis methods. Students will be able to reproduce [...] reproduce the central principles of human genetics and apply a wide range of diagnostic methods. Graduates of this module are able to pursue careers in biomedical/clinical research and diagnostics as well as in [...] the pharmaceutical industry. Competencies Lecture: Students are familiar with modern methods of human genetic diagnostics, in particular the various high-throughput sequencing methods and the procedure for

Basics in Bioinformatics With the participation of lecturers from: Molecular Biology, Human Genetics, Fraunhofer Institute Hannover, Biochemistry, Immunology, HZI Braunschweig, Pathology, Cell Biology, Mi [...] Immunology, Virology, Microbiology, Genetics, Cell Biology and Biochemistry are taught in cooperation with other PhD programs in HBRS as well as partner institutes. In addition, medical students will receive [...] cooperation partners, such as the Helmholtz Institute for Infection Research, HZI, Braunschweig; IPF PharmaCeuticals GmbH (IPF), Hannover; Fraunhofer-Institute of Toxicology and Experimental Medicine, Hannover

cancer is another diagnostic focus of the Institute, both in terms of clinical pathology and research into tumor biology. With regard to clinical pathology, the Institute is used as a consultation and reference [...] carcinoma and resistance to anti-hormonal therapy. The Institute works closely with the West German Study Group and is the reference institution for large therapy studies such as Plan B study Adapt study [...] Schlegelberger B, Kreipe H, Lehmann U. Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer. J Pathol. 2009 Apr;217(5):620-32

genome-wide analyses, i.e. analyses covering the entire human genome. These now allow a more refined description of the molecular changes in human tumors and especially in prostate, urinary bladder and [...] the workers produced by a normal diet. In both cases, the initial organism is genetically similar, i.e. in terms of the genetic information that is written as a sequence in the DNA, but an organism with a [...] risk prediction. Project: Identification of genetic risk factors for prostate cancer The question of whether certain gene variants - i.e. changes in the human DNA sequence - are linked to an increased risk

Human Genetics (BM P 5) Copyright: M. Celik /Präsidialamt - Master Biomedizin /MHH Qualification goals By learning the basics of human genetics and state-of-the-art diagnostic methods, graduates of this [...] the pharmaceutical industry. Competencies Lecture: Students are familiar with modern methods of human genetic diagnostics, in particular the various high-throughput sequencing methods and the procedure for [...] molecular cytogenetic and molecular genetic examination methods and have the skills to differentiate between insignificant normal variants and pathogenic variants in the human genome that are the cause of a

1997–2000 Group Leader (C1) at the Institute of Genetics, University of Bonn Since 2000: Research group leader at the Institute of Cell Biology, merged in 2016 to form the Institute of Neuroanatomy and Cell Biology [...] 2017). Pathomechanisms of neurodegenerative diseases Following the merger of the Institute of Cell Biology with the Institute of Neuroanatomy, I investigated whether changes in endocytosis occur in spinal [...] thesis and doctoral dissertation in the research group of Dr. Ernst Ungewickell at the Max Planck Institute for Biochemistry, Martinsried 1992–1997 Postdoctoral fellow in Dr. Emil Unanue’s research group

Human genetic counseling Human genetic counseling is an important part of patient care for hereditary cancers . Such counseling is available to anyone who is concerned that the illnesses that have occurred [...] predisposition. Both patients and healthy family members can present themselves for human genetic counseling. Genetic counseling is a service provided by statutory health insurance companies and is usually [...] risk of developing the disease whether genetic diagnostics can be carried out in your family and what options or consequences may arise from the results of the genetic diagnostics.

nal cohorts could enable more accurate cancer risk prediction," says Penkert from the Institute of Human Genetics, who is currently conducting research in Professor Kratz's team. A total of 141 people [...] and is associated with a massively increased cancer risk. It represents one of the most important genetic causes of cancer in children and adults. Modern DNA sequencing methods are repeatedly uncovering