brain abnormalities in humans. We found that stress induces muscle degeneration even in wild type animals and accelerates age-dependent muscular dystrophy and that miRNAs are involved in this process. Future

in the selection of marker systems for genotyping and breeding strategies, taking into account the Animal Welfare Act and the Genetic Engineering Act. Authenticity control of the genetic background: mic

such as the lungs are only accessible using specialized methods. Back to the homepage of the Central Animal Laboratory

biological rhythms, which we are slowly beginning to understand. In nature, many processes in plants and animals depend on light and are controlled by it. Over millions of years, the rhythms of life have therefore

Rongsheng Jin at University of California Irvine Research The phrenic nerve hemidiaphragm assay, an animal experiment replacement method for BoNT diagnostics [3] Dr. Andreas Rummel , head of the research [...] their protein receptors, which are used as reagents for the detection of botulinum neurotoxins by animal-free methods for botulism diagnostics and other bacterial protein toxins. Furthermore, Dr. Rummel [...] hemidiaphragm assay, an alternative method for detecting biologically active BoNT [ 3 ], which replaces animal experiments like the mouse lethality assay and the mouse neutralization assay. This assay is also

translational research to clinical and healthcare research. Our investigations range from experimental animal and cell models to blood- and liquor-based biomarkers and clinical studies. Our aim is to gain a

students). Heads the research commission of the MHH (FoKo) Heads the MHH advisory board for the central animal facility, currently represented by Prof. Dr. Reinhold Förster. Cooperation with the Ombudsperson

in vitro models ("Advanced Tissue Culture Models") that avoid exploratory experiments on living animals as far as possible and thus comply with the 3R principle. Research focus / teams: Neuroinfection [...] partners (alphabetical order): Dr. Marijana Basic (Gnotobiology Facility, Institute for Laboratory Animal Science, MHH) Prof. Dr. Nataliya Di Donato (Department of Human Genetics, MHH) Prof. Dr. Lars Dölken

Hospital Hygiene Institute of Virology Institute of Immunology Institute of Laboratory Animal Science and Central Animal Laboratory Institute of Molecular Biology Institute of Transfusion Medicine Institute

hepatocytes by technologies such as gene therapy. Unfortunately, the promising results obtained in animal models could not be successfully transferred into clinical application in man, yet. The aim of our