knowledge already gained from the two use cases in the field of infectiology ( HiGHmed - infection control and SMITH HELP - targeted antibiotic therapy in infectious medicine ) is used and further developed

intracutaneous, epicutaneous) Standardized physical tests (e.g. cold, heat, pressure) Placebo-controlled provocation tests (e.g. oral, subcutaneous, nasal) Special therapy methods Allergen-specific i

crystallization High-Throughput screening of protein crystallization conditions Plate incubation and control of the crystal growth§ Assistance during crystal optimization procedures Buffer optimization Crystal

COVID-19 cohort will encompass a total of 1000 patients with different disease severities and healthy controls. Samples of blood, live blood cells, plasma, serum, saliva, and bronchoalveolar lavage (BAL) will

remodeling). Non-coding RNAs are novel therapeutic targets as critical regulators of gene expression, controlling many physiological and pathological processes. Our primary focus is the development of synthetic [...] patients with heart failure: results of a first-in-human phase 1b randomized, double-blind, placebo-controlled study. European heart journal, 42(2), 178-188. https://doi.org/10.1093/eurheartj/ehaa898 Batkai

were receiving intensive care for severe respiratory infections. These were compared with healthy control kidney tissue, which was obtained from non-diseased areas of the kidneys during kidney operations [...] more than 100,000 individual cells from a total of 12 patients (8 with acute kidney injury and 4 controls without acute kidney injury). Bioinformatic analyses made it possible to assign the sequenced cells

addition, there are a number of local and general (systemic) risk factors, such as smoking or poorly controlled blood sugar (diabetes mellitus), which can promote the development and progression of the disease [...] For example, regenerative periodontal surgery is not very successful in heavy smokers and poorly controlled diabetics. The long-term goal is to restore an inflammation-free periodontium and prevent further

killer cells (NK cells) play the biggest role? What mechanisms do the various immune cells use to control the infection? How efficiently does a single immune cell protect the host organism? To answer these [...] Y, Heller K, Ritter C, Keyser KA, Wagner K, Liu X, Messerle M, Stahl FR*, Halle S*, Förster R*. Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of i

doi: 10.1056/NEJMc2036236. PMID: 33882214 MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate. Gutierrez-Prat N, Cubillos-Rojas M, Cánovas B, Kuzmanic A, Gupta J, Igea [...] MB, Gaestel M. Trends Biochem Sci. 43, 158-167. PDF 2017 p38 MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection Menon MB*, Gropengießer J*, Fischer J, Novikova

prior sensitization to efficiently kill virus-infected and tumor cells enabling them to immediately control until lymphocytes of the adopted immune system overtake and terminate infection and tumorigenesis [...] cells can produce several cytokines such as IFN-γ, TNF-α, GM-CSF and IP10 allowing them to also control and regulate immune functions by soluble factors. Other areas of research: innate immunity, immu