Structural Biochemistry

Director: Prof. Dr. Dietmar Manstein

 

Welcome to the information portal of the Research Core Unit for Structural Biochemistry at Hannover Medical School.

Contact

Name Function Email Phone - Prefix (+49) 511 532
Prof. Dr. Roman Fedorov X-ray crystallography Prof. Dr. Roman Fedorov 3705
Prof. Dr. Ute Curth Analytical Ultracentrifugation Prof. Dr. Ute Curth 9372

 

 

Address:

Research Core Unit for Structural Biochemistry

OE 8830

Building I4, Floor S0

Medizinische Hochschule Hannover

Carl-Neuberg-Str. 1

30625 Hannover

 

The Division for Structural Biochemistry of Hannover Medical School provides support for the following research activities:

 

  • Initial optimization of protein sample for crystallization 
  • High-Throughput screening of protein crystallization conditions
  • Plate incubation and control of the crystal growth§
  • Assistance during crystal optimization procedures
  • Buffer optimization
  • Crystal handling and preparation for cryo-crystallographic data collection
  • Diffraction data collection using sealed-tube and rotating anode x-ray sources
  • Calculating data collection strategies
  • Initial characterization of the crystal cell parameters and Bravais lattice
  • Access to our 3D graphics workstations and computing environment for complete data processing, structure determination and analysis
  • Determination of oligomerization states of proteins and characterization of hydrodynamic properties and macromolecular interactions
  • Finally, we help our users to apply for beamtime at synchrotron facilities. Support is provided for remote and on site access

§For High-Throughput crystallization experiment we use MRC 2 Well Crystallization plate (UVP). These plates provide adequate precision of geometric parameters for nano-dispensing and sufficient transparency in visible and UV range for imaging.

Instruments
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Preparing X-ray Crystallography Samples
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Booking Access to the Infrastructures
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Where To Find Us
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Selected Publications
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