Studies at the Transplant Centre

Prospective, multicenter, comparative study of recurrence-free survival after liver transplantation in two tumor-stage-defined groups (UNOS T2 versus Milan-outZUCSF-in) of patients with hepatocellular carcinoma (HCC) in cirrhosis and locoregional therapy to bridge the waiting period. Applicant: Prof. Dr. Florian W. R. Vondran, Clinical Department of General, Visceral and Transplant Surgery
The safety of the living donor - The German National Living Donor Registry. Risk assessment and development of donor-oriented prevention strategies and standards ("Safety of the living Kidney Donor - The German National Register, SOLKID_GNR"). Applicant: PD Dr. Daniel Pöhnert, Clinic for General, Visceral and Transplant Surgery
Retrospective analysis of liver transplantation in acute toxic liver failure. Applicants: Dr. Ulf Kulik, Prof. Dr. Jürgen Borlak; Clinical Department of General, Visceral and Transplant Surgery
Multicentre, open-label, randomized, two-arm, parallel-group, superiority study to assess practicability of Envarsus® compared with Advagraf® in de novo liver transplant recipients. Applicants: Prof. Dr. Florian Vondran, Dr. Nicolas Richter, Clinical Department of General, Visceral and Transplant Surgery
A multi-center, non-interventional study (NIS) to assess practicability, effectiveness and tolerability of once daily applied tacrolimus formulations used in kidney transplant patients. Applicant: Prof. Dr. Florian Vondran, Chistel Coczur, Clinic for General, Visceral and Transplant Surgery
Functional MRI of the lung and lung function after pediatric lung transplantation. Applicants: Dr. Julia Carlens, Prof. Dr. Jens Vogel-Claussen, Clinical Department of Paediatric Pneumology, Allergology and Neonatology.
3D pulmonary CT segmentation of in vivo transplants (3D PRETOOL) for individualized lung transplantation. Applicants: Prof. Dr. Hoen-oh Sin, Dr. Gesa Helen Pöhler, Dr. Bettina Wiegmann, Dr. Hinrich Boy Winther, Institute of Diagnostic and Interventional Radiology
The influence of glucocorticoid resistance on the cellular rejection reaction after allogeneic lung transplantation. Applicants: Prof. Dr. Danny Jonigk, PD Dr. Stephanie Schubert, Institute of Pathology
The role of CXCL 13 and IL-10 in B-cell infiltration of kidney transplant patients and Sjörgen patients. Applicant: PD Dr. Jan Hinrich Bräsen, Institute of Pathology
Dynamics of Torque-Teno-Virus load before and after initiation of immunosuppression in heart transplantation. Applicants: Dr. univ. Christoph Kleine Vennekate, Dr. Christian Napp, Prof. Dr. Christoph Bara, Clinical Department of Cardiology and Angiology.
Family planning after transplantation. Applicants: Prof. Dr. Frauke von Versen-Höynck, Nadia Meyer, Prof. Dr. Tanja Zimmermann, Clinical Department of Gynaecology and Obstetrics
Implementation of an "Advanced Practice Nurse" in an intensive care unit for visceral and transplant surgery - analysis of the current situation according to the PEPPA framework - quantitative survey of employees. Applicants: Dr. Regina Schmeer, Katharina Büker, Nursing Science,
NTX360º - Physical activity and quality of life in Corona times. Applicant: Prof. Dr. Dr. Uwe Tegtbur, Institute of Sports Medicine
Evaluation of the long-term course of pediatric patients with cystic fibrosis (CF) before and after lung and/or liver transplantation. Applicants: Dr. Eva-Doreen Pfister, Dr. Carsten Müller, Clinical Department of Paediatric Kidney, Liver and Metabolic Diseases
Prospective randomized marker-based study to assess the clinical benefit and safety of biomarker-controlled discontinuation of immunosuppressive therapy after liver transplantation (LIFT). Applicants: Dr. Elmar Jäckel, Prof. Dr. Thomas von Hahn, Clinical Department of Gastroenterology, Hepatology and Endocrinology
Influence of mTOR inhibitors on immune regulation in liver transplant patients. Applicants: PD Dr. Richard Taubert, Dr. Elmar Jaeckel, Clinical Department of Gastroenterology, Hepatology and Endocrinology
Structured counseling and education for patients and their families after liver transplantation in childhood. Applicants: Dr. Johanna Ohlendorf, Dr. Imeke Goldschmidt, Clinical Department of Gastroenterology, Hepatology and Endocrinology
Single cell RNA sequencing of liver biopsies from human allografts. Applicants: PD Dr. Richard Taubert, Bastian Engel, Clinical Department of Gastroenterology, Hepatology and Endocrinology
Lung transplantation in ARDS. Applicant: Prof. Dr. Dr. Jens Gottlieb, Clinical Department of Pneumology
European, multicenter, randomized, double-blind study on pirfenidone in bronchiolitis-obliterans syndrome stage 1-2 in lung transplant recipients (EPOS-CT-001). Applicants: PD Dr. Jens Gottlieb, Dr. Mark Greer, Dr. Edith Katharina Podewski, Dr. Anna Buck, Clinical Department of Pneumology
A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (LCsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BOSTON-3). Applicants: Prof. Dr. Jens Gottlieb, Dr. Kathrin Fricke, Clinical Department of Pneumology
DNA-based testing of BAL in suspected lower respiratory tract infection after lung transplantation (DBATE-IT). Applicants: Prof. Dr. Jens Gottlieb, Dr. Benjamin Seeliger, Clinical Department of Pneumology
Viral load guided Immunosuppression after Lung Transplantation - An open-label, randomized, controlled, parallel-group, multicenter trial (VIGILung). applicants: Prof. Dr. Jens Gottlieb, Dr. Mark Greer, Clinical Department of Pneumology.
Effect of additional education using comics on patient satisfaction and anxiety reduction during bronchoscopies in the routine follow-up of lung transplant patients (comic-assisted bronchoscopy education, COBRA). Applicants: Prof. Dr. Jens Gottlieb, Dr. Benjamin Seeliger, Clinical Department of Pneumology
Retrospective real world evaluation of long-term kidney graft survival in patients on ADVAGRAFTM based immunosuppression at three transplant centers in Germany. Applicant: Prof. Dr. Dr. Wilfried Gwinner, Clinical Department of Nephrology
Investigation of the antiviral immune response as an indicator for intensity of immunosuppression and outcome after kidney transplantation. Applicants: Prof. Dr. Dr. Gunilla Einecke, Prof. Dr. Jan Menne, Clinical Department of Nephrology
A 12 month, partially-blinded, active-controlled, multicenter, randomized study evaluating efficacy, safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) of an anti-CD40 monoclonal antibody, CFZ533, in de novo and maintenance kidney transplant recipients (CIRRUS I). Applicants: Prof. Dr. Dr. Gunilla Einecke, Prof. Dr. Florian Vondran, Clinical Department of Nephrology
A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for the Treatment of Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients. Applicants: Prof. Dr. Hermann Haller, Prof. Dr. Jan Menne, Clinical Department of Nephrology
A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of MK-8228 (Letermovir) Versus Valganciclovir for the Prevention of Human Cytomegalovirus (CMV) Disease in Adult Kidney Transplant Recipients. Applicants: Prof. Dr. Hermann Haller, Prof. Dr. Jan Menne, Clinical Department of Nephrology
Prognostic value of non-cytotoxic HLA antibodies for kidney transplantation. Applicants: PD Dr. Malte Ziemann, PD Dr. Dr. Gunilla Einecke, Clinical Department of Nephrology
Influence of the incidence of fungal infections and acute transplant rejection depending on the antibiotic classes administered - a retrospective data analysis in the cohort of patients after lung transplantation. Applicants: Dr. Christine Fegbeutel, Ilona Maeding, Clinical Department of Cardiothoracic, Transplantation and Vascular Surgery
OCS Lung INSPRIRE long-term follow-up - continuation study of the prospective international multicenter randomized clinical trial of the Organ Care System™ (OSC) from TransMedics® for the protection and transplantation of lungs (INSPIRE study). Applicants: Prof. Dr. Dr. Gregor Warnecke, Susanne Freyt, Clinical Department of Cardiothoracic, Transplantation and Vascular Surgery
Continuous monitoring of pulmonary pressure (PAP) during left ventricle assist device (LVAD) support: impact on cardiac transplantation candidacy - The MEM-VAD Study. Applicant: Prof. Dr. Dr. Jan D. Schmitto Clinical Department of Cardiothoracic, Transplantation and Vascular Surgery
Behavioral and nutritional intervention for weight reduction in adult kidney transplant patients with overweight or obesity. Applicants: Dr. Mariel Nöhre, Prof. Dr. Martina de Zwaan, Clinical Department of Psychosomatics and Psychotherapy
Mental health and quality of life in heart transplant candidates and patients after heart transplantation. Applicants: Dr. Mariel Nöhre, Prof. Dr. Martina de Zwaan, Prof. Dr. Christoph Bara, PD Dr. Adelheid, Clinical Department of Psychosomatics and Psychotherapy