monoculture and in co-culture with astrocytes/microglia obtained from the transgenic ALS animal model or healthy control animals, as well as in vivo studies in the G93A-SOD1 mouse model and neuropathological studies [...] R. Esser) in order to initiate an initial clinical evaluation following the completion of ongoing animal studies. Neuroprotective effects of genetic deletion of fibroblast growth factor 2 (FGF-2) in astrocytes

clinically tested in Europe. Animal organs could also be used as temporary replacements. At the Transplant Summit, a team from Hanover presented a procedure in which animal livers temporarily take over [...] research is also being carried out to further develop alternatives such as the transplantation of animal organs (xenotransplantation) or cultivated miniature organs (organoids) and prepare them for testing [...] tissue. Xenotransplantation - are we ready for translation into patients? The transplantation of animal organs (xenotransplantation) is an old concept; however, it is only in the last ten years that major

opportunity to gain knowledge about and with the animal through direct practical relevance. As part of the practical work, such as feeding the animals, collecting the eggs, cleaning the coop and observing [...] coop in the outdoor area of the daycare center. The children were able to observe and care for the animals from 10.10. - 7.11.2022 under the supervision and guidance of the specialists. Children can learn [...] learn a lot with and from chickens. With this project, we enabled the girls and boys to relate to animals with the aim of absorbing a wide range of learning content on the environment, nature and sustainable

molecular biology, histology, immunohistology, immunohistochemistry and cell biology, as well as in animal models. This is made possible by the latest equipment, such as a flow cytometer equipped with four [...] and a digital 4K microscope are used to analyze the preparations. Our laboratory also has its own animal operating room for mice and rats with an isoflurane anesthesia and suction unit. You can find more

of the area is complemented by additional rooms for data processing, project meetings, storage and animal husbandry. The supply of radiopharmaceuticals for various examinations, as well as quality control [...] Protection/Medical Physics Unit . The department is operated in close coordination with the central animal laboratory of the MHH . A permanent staff (laboratory manager, technical assistants, laboratory

point for a joint scientific project or a cooperation within the framework of a clinical study or an animal experiment. Please note Due to staff shortages, there are currently only a limited number of consultation [...] than the day before the consultation appointment. If you already have a study protocol (draft) or an animal experiment application, please also send us these documents at least one day before the consultation

poisoning. Until now, this has mostly been done using animal tests, animal products or the so-called monocyte activation test (MAT). But the use of animal tests and products must be avoided - also because

Medical Center Utrecht these tissues are transplanted for preclinical testing into damaged hearts in animal models. Monitoring the (electro-) physiological integration of the transplanted cells is another [...] Endothelial cells (ECs) and pericytes (PCs) differentiation WP 7 Mesenchymal Stem Cells (MSC) WP 8 Large animal model, in vivo cell monitoring and function WP 9 Regulatory compliance and exploitation WP 10 Management

Research report 2018 The animation or cover image shows hybrid imaging of the heart with positron emission tomography (PET) / X-ray computed tomography (CT) in a patient 5 days after an acute myocardial [...] However, we would like to take the opportunity here to explicitly present a representative project. Animation Copyright: Bengel, Clinical Department of Nuclear Medicine, MHH Imprint Publisher: President of

Project presentation 2019 The animation or cover image shows the innovative "prime editing" process for precisely correcting DNA changes in cells. In this process, the CRISPR/Cas9 system is guided precisely [...] aim of the work is also to investigate future forms of application directly in the organism. The animation was created by Prof. Dr. med. Tobias Cantz (Translational Hepatology and Stem Cell Biology working